PDE4 modulates muscle signaling in cancer cachexia.
1/5 보강
The bioenergetic crisis in cancer cachexia arises from early mitochondrial dysfunction that precipitates muscle wasting.
APA
Fan R, Zhang B, Wei G (2026). PDE4 modulates muscle signaling in cancer cachexia.. Trends in pharmacological sciences, 47(2), 128-130. https://doi.org/10.1016/j.tips.2025.11.009
MLA
Fan R, et al.. "PDE4 modulates muscle signaling in cancer cachexia.." Trends in pharmacological sciences, vol. 47, no. 2, 2026, pp. 128-130.
PMID
41372029 ↗
Abstract 한글 요약
The bioenergetic crisis in cancer cachexia arises from early mitochondrial dysfunction that precipitates muscle wasting. In a recent study, Angelino et al. found that tumor-derived signals suppress the cAMP-protein kinase A (PKA)-CREB1 axis, destabilizing mitochondrial homeostasis. Restoring cAMP signaling through phosphodiesterase 4 (PDE4) inhibition rescued mitochondrial function, highlighting a promising strategy to mitigate tumor-induced cachexia.
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