Analysis of the clinicopathological relevance and prognostic value of CDK1 in human malignancy: Insights from meta and bioinformatics analysis.
1/5 보강
We conducted a comprehensive assessment of the prognostic significance of CDK1 expression in patients diagnosed with cancer.
- 95% CI 1.31-1.81
- OR 1.50
- 연구 설계 meta-analysis
APA
Pashirzad M, Butler AE, et al. (2026). Analysis of the clinicopathological relevance and prognostic value of CDK1 in human malignancy: Insights from meta and bioinformatics analysis.. Surgical oncology, 64, 102339. https://doi.org/10.1016/j.suronc.2025.102339
MLA
Pashirzad M, et al.. "Analysis of the clinicopathological relevance and prognostic value of CDK1 in human malignancy: Insights from meta and bioinformatics analysis.." Surgical oncology, vol. 64, 2026, pp. 102339.
PMID
41422775 ↗
Abstract 한글 요약
We conducted a comprehensive assessment of the prognostic significance of CDK1 expression in patients diagnosed with cancer. Pooled hazard ratios (HRs), odds ratios (ORs), and 95 % confidence interval (CI) were calculated to determine the associations between CDK1 expression and overall survival (OS), disease-free survival (DFS), as well as various clinicopathological characteristics. A total of 20 studies, comprising 2470 patients, were included in this meta-analysis. Elevated CDK1 expression was significantly associated with reduced OS in both univariate and multivariate analyses, with pooled HRs of 1.55 (95 % CI: 1.31-1.81) and 1.89 (95 % CI: 1.52-2.36), respectively. Furthermore, higher CDK1 expression levels correlated significantly with adverse pathological features, including tumor size (OR = 1.50; 95 % CI, 1.08-2.09), lymph node metastasis (LNM; OR = 2.41; 95 % CI, 1.69-3.44), higher histological grade (OR = 2.40; 95 % CI, 1.69-3.39) and advanced tumor stage (OR = 1.76; 95 % CI, 1.25-2.48). These findings suggest that CDK1 over-expression may serve as a robust prognostic biomarker associated with unfavorable clinical outcomes in patients with cancer.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.