YY1 in four dimensions: From context-dependent transcription factor to spatiotemporal gene regulator.
1/5 보강
YY1 is a multifunctional transcription factor whose regulation spans transcriptional, post-transcriptional, and post-translational layers, conferring remarkable context-dependent plasticity.
APA
Vivarelli S, Falzone L, et al. (2026). YY1 in four dimensions: From context-dependent transcription factor to spatiotemporal gene regulator.. Biochimica et biophysica acta. Reviews on cancer, 1881(1), 189526. https://doi.org/10.1016/j.bbcan.2025.189526
MLA
Vivarelli S, et al.. "YY1 in four dimensions: From context-dependent transcription factor to spatiotemporal gene regulator.." Biochimica et biophysica acta. Reviews on cancer, vol. 1881, no. 1, 2026, pp. 189526.
PMID
41490532 ↗
Abstract 한글 요약
YY1 is a multifunctional transcription factor whose regulation spans transcriptional, post-transcriptional, and post-translational layers, conferring remarkable context-dependent plasticity. Several studies carried out in YY1-deficient mouse models highlight its essential roles in embryogenesis, organogenesis, and cellular homeostasis, while its deregulation in adulthood predisposes to multiple chronic diseases. In cancer, YY1 displays a bidirectional function, acting as either oncogene or tumor suppressor depending on cellular context and tumor type, and reshaping transcriptional and epigenetic networks. Emerging evidence further identifies YY1 as a clock-controlled gene and architectural regulator of circadian transcription, bridging together enhancer-promoter communication, chromatin state, and the temporal dimension of gene expression. In this context, its deregulation links circadian misalignment with oncogenic signaling, underscoring its key role as a diagnostic and prognostic biomarker, as well as a therapeutic target, thus highlighting its relevance in precision oncology.
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