miRNA-HK2 networks in cancer metabolism: Mechanisms and dual-targeting therapeutic opportunities.
Metabolic reprogramming, exemplified by the Warburg effect, is a hallmark of cancer.
APA
Jiang X, Li X, et al. (2026). miRNA-HK2 networks in cancer metabolism: Mechanisms and dual-targeting therapeutic opportunities.. Biochimica et biophysica acta. Reviews on cancer, 1881(1), 189530. https://doi.org/10.1016/j.bbcan.2026.189530
MLA
Jiang X, et al.. "miRNA-HK2 networks in cancer metabolism: Mechanisms and dual-targeting therapeutic opportunities.." Biochimica et biophysica acta. Reviews on cancer, vol. 1881, no. 1, 2026, pp. 189530.
PMID
41506330
Abstract
Metabolic reprogramming, exemplified by the Warburg effect, is a hallmark of cancer. Hexokinase 2 (HK2), a key glycolytic enzyme, is frequently overexpressed in cancer, sustaining glucose metabolism and tumor progression. MicroRNAs (miRNAs) post-transcriptionally regulate HK2 by targeting its 3'untranslated region or upstream signaling pathways. While monotherapies often fail due to compensatory pathways and drug resistance, dual-targeting both HK2 and its regulatory miRNAs could achieve substantial metabolic inhibition. This review summarizes recent advances in miRNA-HK2 regulatory networks across cancers and highlights dual-targeting miRNA-HK2 as a promising therapeutic strategy to overcome metabolic plasticity and improve precision, durability, and efficacy in cancer therapy.
MeSH Terms
Humans; Neoplasms; Hexokinase; MicroRNAs; Gene Expression Regulation, Neoplastic; Animals; Signal Transduction; Molecular Targeted Therapy; Glycolysis; Gene Regulatory Networks
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