Current status and perspective of off-the-shelf CAR-T cells in cancer immunotherapy.
1/5 보강
Recent advances in cancer immunotherapy have highlighted the promise of off-the-shelf chimeric antigen receptor (CAR)-T cell therapy.
APA
Fallahianshafiei S, Babaeizad A, et al. (2026). Current status and perspective of off-the-shelf CAR-T cells in cancer immunotherapy.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 195, 118986. https://doi.org/10.1016/j.biopha.2026.118986
MLA
Fallahianshafiei S, et al.. "Current status and perspective of off-the-shelf CAR-T cells in cancer immunotherapy.." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, vol. 195, 2026, pp. 118986.
PMID
41512559 ↗
Abstract 한글 요약
Recent advances in cancer immunotherapy have highlighted the promise of off-the-shelf chimeric antigen receptor (CAR)-T cell therapy. This has offered solutions to key limitations of conventional autologous approaches, such as patient-specific cell collection and lengthy production times. This review summarizes the development, clinical application, and challenges of CAR-T cell technology. We reviewed CAR design and function, cancer-targeting mechanisms, and approaches to developing universal donor platforms that could replace the need for patient-specific cell harvesting. We discussed key challenges of CAR-T technology and its potential solutions. This review also summarizes CAR-T cell therapies recently approved by the FDA. Finally, we explored future directions, regulatory challenges and the potential of personalized medicine, emphasizing how off-the-shelf CAR-T therapies could revolutionize cancer treatment by making it more scalable and accessible.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Neoplasms
- Immunotherapy
- Adoptive
- Receptors
- Chimeric Antigen
- Animals
- T-Lymphocytes
- Precision Medicine
- Antigen
- T-Cell
- Allogeneic CAR-T cells
- Cancer immunotherapy
- FDA-approved CAR-T cells
- Immune rejection
- Personalized cancer treatment
- Regulatory landscape
- Tumor heterogeneity
- Universal CAR-T cells
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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