Lung and Bronchus Cancer - 20-Year Comparative Mortality and Survival Analysis by Age, Sex, Race/Ethnicity, Stage, Grade, Disease Duration, Selected ICD-O-3 Oncophenotypes, and Cohort Entry Time-Period: A Systematic Review of 588,785 Cases for Diagnosis Years 1975-2022.

Cancers of the lung and bronchus are broad terms for a common, deadly, complex, heterogenous and histologically diverse group of respiratory malignancies that comprise the leading cause of global cancer incidence and mortality accounting for an estimated 2 million diagnoses and 1.8 million deaths, and occurs through a complicated multistage process that results from the combination of carcinogen exposure, the primary etiology of which is tobacco smoking and genetic susceptibilities. This pathologic scourge is the second most common cause of cancer in men and women (after prostate and breast cancer, respectively). The mean age of diagnosis by sex is 67 years old and by race in Whites-67, Blacks-64, Others (AI/AN-American Indian/Alaska Native, API-Asian/Pacific Islander)-66 years. In this short and long term retrospective population-based analysis of 588,785 microscopically confirmed lung and bronchus case mortality and survival study, data is derived from the National Cancer Institute (NCI) Surveillance, Epidemiology, End-Results programs, SEER*Stat software version 9.0.42 released October 19, 2025, and SEER Registry (Incidence - SEER Research Data, 8 Registries, Nov 2024 Submission (1975-2022) released April 2025. This comparative cohort entry time-period analysis is intended to provide age-adjusted epidemiologic, demographic short and long-term survival and mortality data for convenient reference by all physicians, scientists, insurance underwriters and others interested in cancer mortality follow-up.