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Metastatic Melanoma Mimicking Primary Breast Cancer-A Diagnostic Challenge: A Case Report.

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Case reports in pathology 2026 Vol.2026() p. 8820195
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Rezende AS, Gutman TCF, Stumpf MVTC, Cunha KSG, Rodrigues FR, Lopes VGS

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[INTRODUCTION] Metastatic melanoma to the breast is rare and may be misdiagnosed as primary breast carcinoma.

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APA Rezende AS, Gutman TCF, et al. (2026). Metastatic Melanoma Mimicking Primary Breast Cancer-A Diagnostic Challenge: A Case Report.. Case reports in pathology, 2026, 8820195. https://doi.org/10.1155/crip/8820195
MLA Rezende AS, et al.. "Metastatic Melanoma Mimicking Primary Breast Cancer-A Diagnostic Challenge: A Case Report.." Case reports in pathology, vol. 2026, 2026, pp. 8820195.
PMID 41743380

Abstract

[INTRODUCTION] Metastatic melanoma to the breast is rare and may be misdiagnosed as primary breast carcinoma. Histological, immunohistochemical, and clinical correlations, such as a history of previous melanoma, are essential for diagnosis.

[PATIENT PRESENTATION] A female patient presented with melanoma in the left gluteal region. Five years later, a palpable nodule was detected in the right breast on routine mammography. Microscopic and immunohistochemical examination confirmed the diagnosis of metastatic melanoma. The patient passed away 3 years later.

[CONCLUSION] The findings in this case indicate that metastatic melanoma can present in atypical ways and that specialists should pay attention to metastases in unusual locations in cases of melanoma.