TfOH-triggered denitrogenative union of diazo carbonyl compounds and indolin-2-thiones toward functionalized indole derivatives and their preliminary anticancer assessment.
1/5 보강
A metal-free, chemoselective TfOH-mediated union of α-diazo carbonyl compounds and indolin-2-thiones to access functionalized indoles has been disclosed.
APA
Sable SH, Ambadipudi SSSSS, et al. (2026). TfOH-triggered denitrogenative union of diazo carbonyl compounds and indolin-2-thiones toward functionalized indole derivatives and their preliminary anticancer assessment.. Organic & biomolecular chemistry, 24(8), 1697-1702. https://doi.org/10.1039/d5ob01227a
MLA
Sable SH, et al.. "TfOH-triggered denitrogenative union of diazo carbonyl compounds and indolin-2-thiones toward functionalized indole derivatives and their preliminary anticancer assessment.." Organic & biomolecular chemistry, vol. 24, no. 8, 2026, pp. 1697-1702.
PMID
41649319 ↗
Abstract 한글 요약
A metal-free, chemoselective TfOH-mediated union of α-diazo carbonyl compounds and indolin-2-thiones to access functionalized indoles has been disclosed. Interestingly, indolin-2-thiones treated with α-diazo esters delivered indolyl thioethers through formal S-H insertion, and α-diazo ketones provided fused hybrid heterocyclic systems, thiazolo[3,2-]indoles, through a cascade process involving S-H insertion, cyclization, and dehydration. Furthermore, these newly synthesized compounds showed promising anti-cancer activities against breast cancer and prostate cancer cell models.
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