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Combined 6th and 12th Cranial Nerve Palsies (Godtfredsen Syndrome) due to Clival Lesions.

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Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2026 Vol.46(1) p. 18-21
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Ishihara RT, Zhao Z, Rajendran S, Sharifi A, Tseng A, DeZeeuw Z

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[BACKGROUND] Godtfredsen syndrome (GS), originally described by Dr.

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APA Ishihara RT, Zhao Z, et al. (2026). Combined 6th and 12th Cranial Nerve Palsies (Godtfredsen Syndrome) due to Clival Lesions.. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 46(1), 18-21. https://doi.org/10.1097/WNO.0000000000002233
MLA Ishihara RT, et al.. "Combined 6th and 12th Cranial Nerve Palsies (Godtfredsen Syndrome) due to Clival Lesions.." Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, vol. 46, no. 1, 2026, pp. 18-21.
PMID 40369741 ↗

Abstract

[BACKGROUND] Godtfredsen syndrome (GS), originally described by Dr. Erik Godtfredsen in 1946, is the combination of cranial nerve (CN) 6th and 12th palsies. The most common etiology of GS is a lesion of the clivus.

[METHODS] A retrospective case series of GS is described.

[RESULTS] Three patients were included: 1) a 38-year-old woman with a clival breast cancer metastasis; 2) a 35-year-old woman with a clival chordoma; and 3) a 72-year-old woman with a partially embolized dural arteriovenous fistula involving the hypoglossal canal.

[CONCLUSIONS] GS is a combination of CN 6th and 12th palsies and most commonly is due to a lesion in the clivus. Clinicians should be aware of this uncommon combination of cranial nerve findings, the localizing significance, and the differential diagnosis of clival lesions.

🏷️ 키워드 / MeSH 📖 같은 키워드 OA만

🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반