Circulating tumor DNA as a biomarker in early phase clinical trials.
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The clinical development of novel cancer therapeutics is rapidly evolving with the integration of molecular biomarkers to advance precision medicine.
APA
Tan HN, Elliott MJ, et al. (2026). Circulating tumor DNA as a biomarker in early phase clinical trials.. Cancer cell, 44(2), 240-247. https://doi.org/10.1016/j.ccell.2025.11.011
MLA
Tan HN, et al.. "Circulating tumor DNA as a biomarker in early phase clinical trials.." Cancer cell, vol. 44, no. 2, 2026, pp. 240-247.
PMID
41418771 ↗
Abstract 한글 요약
The clinical development of novel cancer therapeutics is rapidly evolving with the integration of molecular biomarkers to advance precision medicine. Circulating tumor DNA (ctDNA) represents a versatile tool to detect targetable alterations, predict therapeutic response, monitor tumor evolution, and inform pharmacokinetic and pharmacodynamic effects. This could accelerate early phase drug development and deepen our understanding of biological drivers of response and resistance. Herein, we highlight current applications and future opportunities for ctDNA as a multi-utility biomarker in early phase clinical trials.
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