Back with Weight: Revisiting Very Heavy Ions for Precision Radiotherapy.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 3/4)
유사 논문P · Population 대상 환자/모집단
환자: particles ranging from helium to argon
I · Intervention 중재 / 시술
treatment with helium ions, which have biological effects similar to those of protons
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Their associated toxicity may be mitigated by employing approaches such as ultra-high-dose-rate (FLASH) or spatially fractionated radiotherapy. Current plans and prospects for the clinical application of neon ions will be discussed.
Accelerated charged particles offer significant physical advantages over X rays in radiotherapy.
APA
Jansen J, Sokol O, et al. (2026). Back with Weight: Revisiting Very Heavy Ions for Precision Radiotherapy.. Radiation research, 205(2), 113-128. https://doi.org/10.1667/RADE-25-00177.1
MLA
Jansen J, et al.. "Back with Weight: Revisiting Very Heavy Ions for Precision Radiotherapy.." Radiation research, vol. 205, no. 2, 2026, pp. 113-128.
PMID
41448585 ↗
Abstract 한글 요약
Accelerated charged particles offer significant physical advantages over X rays in radiotherapy. In addition to their superior depth-dose distribution, heavy ions offer notable biological benefits over protons. Specifically, at therapeutic energies, very heavy ions are expected to exhibit high relative biological effectiveness and a low oxygen enhancement ratio, making them potentially ideal for treating radioresistant tumors. Over fifty years ago, the Lawrence Berkeley Laboratory started a clinical trial to treat cancer patients with particles ranging from helium to argon. However, treatments with ions of atomic number greater than 10 proved highly toxic to normal tissue. Most patients ultimately received treatment with helium ions, which have biological effects similar to those of protons. In recent years, novel strategies have emerged that can reduce normal tissue toxicity in radiotherapy while preserving tumor control. These advancements open the possibility of revisiting the clinical use of heavier ions. In this paper, we propose that neon ions may serve as an effective modality for treating resistant, hypoxic tumors. Their associated toxicity may be mitigated by employing approaches such as ultra-high-dose-rate (FLASH) or spatially fractionated radiotherapy. Current plans and prospects for the clinical application of neon ions will be discussed.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.