Value of Dual-Energy Computed Tomography Quantitative Parameters in Evaluating the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer.
[RATIONALE AND OBJECTIVES] To investigate the value of dual-energy computed tomography (DECT) quantitative parameters and their percentage changes for evaluating the therapeutic response to neoadjuvan
- 표본수 (n) 18
- p-value P < 0.05
APA
Xiang R, Peng X, et al. (2026). Value of Dual-Energy Computed Tomography Quantitative Parameters in Evaluating the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer.. Academic radiology. https://doi.org/10.1016/j.acra.2026.02.001
MLA
Xiang R, et al.. "Value of Dual-Energy Computed Tomography Quantitative Parameters in Evaluating the Efficacy of Neoadjuvant Chemotherapy for Breast Cancer.." Academic radiology, 2026.
PMID
41781263
Abstract
[RATIONALE AND OBJECTIVES] To investigate the value of dual-energy computed tomography (DECT) quantitative parameters and their percentage changes for evaluating the therapeutic response to neoadjuvant chemotherapy (NAC) in breast cancer.
[MATERIALS AND METHODS] Clinical data from 43 patients with histologically confirmed breast cancer who underwent contrast-enhanced DECT scans before and after NAC were retrospectively analyzed. Based on the postoperative Miller-Payne (MP) grading system, patients were classified into an effective group (MP grades 4-5, n = 18) and an ineffective group (MP grades 1-3, n = 25). Quantitative parameters-including normalized iodine concentration (NIC), spectral slope (λHU), and electron density (ED)-were measured before and after NAC. The percentage changes (ΔNIC%, ΔλHU%, and ΔED%) were calculated and compared between the two groups.
[RESULTS] Before NAC, no statistically significant differences were observed in any of the quantitative parameters (NIC, λHU, and ED) between the effective and ineffective groups (P > 0.05). After NAC, the effective group showed significantly greater ΔNIC% and ΔλHU% in the arterial phase, as well as significantly greater ΔNIC%, ΔλHU%, and ΔED% in the venous phase than did the ineffective group (all P < 0.05).
[CONCLUSION] Changes in DECT-derived quantitative parameters, especially venous-phase ΔNIC%, ΔλHU%, and ΔED%, were associated with response to neoadjuvant chemotherapy in breast cancer, indicating the potential of DECT-based metrics to support imaging evaluation of treatment response.
[MATERIALS AND METHODS] Clinical data from 43 patients with histologically confirmed breast cancer who underwent contrast-enhanced DECT scans before and after NAC were retrospectively analyzed. Based on the postoperative Miller-Payne (MP) grading system, patients were classified into an effective group (MP grades 4-5, n = 18) and an ineffective group (MP grades 1-3, n = 25). Quantitative parameters-including normalized iodine concentration (NIC), spectral slope (λHU), and electron density (ED)-were measured before and after NAC. The percentage changes (ΔNIC%, ΔλHU%, and ΔED%) were calculated and compared between the two groups.
[RESULTS] Before NAC, no statistically significant differences were observed in any of the quantitative parameters (NIC, λHU, and ED) between the effective and ineffective groups (P > 0.05). After NAC, the effective group showed significantly greater ΔNIC% and ΔλHU% in the arterial phase, as well as significantly greater ΔNIC%, ΔλHU%, and ΔED% in the venous phase than did the ineffective group (all P < 0.05).
[CONCLUSION] Changes in DECT-derived quantitative parameters, especially venous-phase ΔNIC%, ΔλHU%, and ΔED%, were associated with response to neoadjuvant chemotherapy in breast cancer, indicating the potential of DECT-based metrics to support imaging evaluation of treatment response.
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