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The impacts of ribociclib on the post-treatment Tp-e interval and Tp-e/QTc ratio in breast cancer patients.

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Advances in medical sciences 2026 Vol.71(1) p. 83-87
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Çiriş Ş, Seyyar M, Yaman İ, Polat E

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[PURPOSE] The study aimed to assess the impacts of ribociclib on the post-treatment Tp-e interval and Tp-e/QTc ratio in breast cancer patients.

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  • p-value p < 0.05

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↓ .bib ↓ .ris
APA Çiriş Ş, Seyyar M, et al. (2026). The impacts of ribociclib on the post-treatment Tp-e interval and Tp-e/QTc ratio in breast cancer patients.. Advances in medical sciences, 71(1), 83-87. https://doi.org/10.1016/j.advms.2026.03.002
MLA Çiriş Ş, et al.. "The impacts of ribociclib on the post-treatment Tp-e interval and Tp-e/QTc ratio in breast cancer patients.." Advances in medical sciences, vol. 71, no. 1, 2026, pp. 83-87.
PMID 41812826 ↗
DOI 10.1016/j.advms.2026.03.002

Abstract

[PURPOSE] The study aimed to assess the impacts of ribociclib on the post-treatment Tp-e interval and Tp-e/QTc ratio in breast cancer patients.

[MATERIALS/METHODS] A retrospective study was carried out with 40 breast cancer patients between October 2023 and February 2024 to reveal the impacts of ribociclib therapy (either alone or in combination with letrozole) on the post-treatment Tp-e interval and Tp-e/QTc ratio. ECGs obtained before the start of the treatment and on the 21st day of the 3rd course were used in the evaluation.

[RESULTS] Patients' pre-treatment heart rate, WBC, AST, QRS (ms), Tp-e/QT, and Tp-e/JT values decreased after the treatment (p < 0.05). Patients' pre-treatment QT, JT (ms), JTc(ms), Tp-e(ms), Tp-e/Qtc, and Tp-e/JTc values increased after the treatment (p < 0.05). Patients' pre- and post-treatment ionized Ca/(Tpe/JTc) values showed statistically significant difference (p < 0.01). The pre-treatment ionized Ca/(Tpe/JTc) values of patients decreased significantly after the treatment. The ionized Ca/(Tpe/QTc) values of patients differed statistically significantly before and after the treatment (p < 0.01). Patients' pre-treatment ionized Ca/(Tpe/QTc) values decreased significantly after the treatment.

[CONCLUSION] The potential arrhythmogenic effects of ribociclib suggest that serum calcium (Ca), ionized calcium, QT, QTc, Tp-e interval, and Tp-e/QTc ratio may be monitored throughout the treatment period.

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