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A practical approach for assessing high-grade diffuse gliomas and meningiomas.

Human pathology 2026 Vol.169() p. 106022

Zhu Y, Rudolf MA, Conway K, Trejo-Lopez JA, Camelo-Piragua S, Raghunathan A

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The field of central nervous system (CNS) tumor diagnostics continues to evolve and expand with the emergence and integration of diagnostic, prognostic, and predictive genomic markers.

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APA Zhu Y, Rudolf MA, et al. (2026). A practical approach for assessing high-grade diffuse gliomas and meningiomas.. Human pathology, 169, 106022. https://doi.org/10.1016/j.humpath.2025.106022
MLA Zhu Y, et al.. "A practical approach for assessing high-grade diffuse gliomas and meningiomas.." Human pathology, vol. 169, 2026, pp. 106022.
PMID 41419116

Abstract

The field of central nervous system (CNS) tumor diagnostics continues to evolve and expand with the emergence and integration of diagnostic, prognostic, and predictive genomic markers. Despite such ever-increasing complexity, it remains within the ability of practicing surgical pathologists to perform an informed assessment of a majority of CNS tumors. In this review, we provide practical guidelines to evaluate the most common primary malignant and benign CNS tumor entities - high-grade diffuse glioma and meningioma.

MeSH Terms

Humans; Meningioma; Glioma; Neoplasm Grading; Meningeal Neoplasms; Biomarkers, Tumor; Brain Neoplasms

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