Cuproptosis in cancer: from molecular mechanisms to therapeutic intervention.
1/5 보강
Cuproptosis, a recently discovered form of regulated cell death triggered by copper overload, is distinguished by the aggregation of lipoylated mitochondrial proteins and destabilization of iron-sulfu
APA
Jiang D, Zhuang L, et al. (2026). Cuproptosis in cancer: from molecular mechanisms to therapeutic intervention.. Trends in cancer, 12(3), 275-286. https://doi.org/10.1016/j.trecan.2025.12.002
MLA
Jiang D, et al.. "Cuproptosis in cancer: from molecular mechanisms to therapeutic intervention.." Trends in cancer, vol. 12, no. 3, 2026, pp. 275-286.
PMID
41419376 ↗
Abstract 한글 요약
Cuproptosis, a recently discovered form of regulated cell death triggered by copper overload, is distinguished by the aggregation of lipoylated mitochondrial proteins and destabilization of iron-sulfur cluster proteins. Given the altered copper metabolism and metabolic dependencies of cancer cells, cuproptosis might represent a unique vulnerability with therapeutic potential. In this review we summarize current knowledge of copper homeostasis, the molecular mechanisms of cuproptosis and its roles in cancer biology. We highlight therapeutic strategies that harness cuproptosis, including copper ionophores, nanomedicine, and rational combination therapies, and discuss challenges such as systemic toxicity, resistance mechanisms, and biomarker development. Finally, we outline key questions and future directions for translating cuproptosis into the clinic.
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