The role of cardiac imaging for diagnosis of cardiac amyloidosis: a systematic review and meta-analysis of test accuracy.
메타분석
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
환자: biopsy proven light-chain (AL) amyloidosis
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Certainty of evidence was very low. [CONCLUSION] CMR might be more accurate than echocardiography for diagnosis of cardiac involvement in AL amyloidosis.
[OBJECTIVE] To evaluate the diagnostic test accuracy of cardiac magnetic resonance (CMR) and echocardiography for diagnosis of cardiac involvement in patients with biopsy proven light-chain (AL) amylo
- Specificity 95%
- 연구 설계 systematic review
APA
Kawtharany H, Azzam M, et al. (2026). The role of cardiac imaging for diagnosis of cardiac amyloidosis: a systematic review and meta-analysis of test accuracy.. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 33(1), 59-71. https://doi.org/10.1080/13506129.2025.2596145
MLA
Kawtharany H, et al.. "The role of cardiac imaging for diagnosis of cardiac amyloidosis: a systematic review and meta-analysis of test accuracy.." Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, vol. 33, no. 1, 2026, pp. 59-71.
PMID
41479129 ↗
Abstract 한글 요약
[OBJECTIVE] To evaluate the diagnostic test accuracy of cardiac magnetic resonance (CMR) and echocardiography for diagnosis of cardiac involvement in patients with biopsy proven light-chain (AL) amyloidosis.
[METHODS] This systematic review addresses late gadolinium enhancement (LGE) on CMR and different echocardiographic findings for cardiac involvement using an acceptable reference standard. Meta-analysis reported sensitivity and specificity with 95% confidence intervals when we have ≥3 studies, or ranges for 2 studies. We assessed certainty of evidence using GRADE (Grading of Recommendations Assessment, Development, and Evaluation).
[RESULTS] Seven studies evaluated LGE, yielding pooled sensitivity and specificity of 0.95 (0.87-0.98) and 0.87 (0.76-0.94). Nineteen studies addressed echocardiography. Interventricular septum thickness showed sensitivity of 0.77 (0.69-0.84) and specificity of 0.71 (0.60-0.81). Diastolic dysfunction (grade 2-3) sensitivity was 0.71 (0.40-0.90) and specificity was 0.75 (0.64-0.84); restrictive filling pattern (grade 3) sensitivity was 0.42 (0.28-0.58) and specificity 0.89 (0.83-0.94). E/A ratio sensitivity ranged from 0.45 to 0.65, with specificity from 0.85 to 0.98. Global longitudinal strain sensitivity was 0.86 (0.65-0.95) and specificity was 0.76 (0.55-0.89). Apical sparing pattern showed sensitivity of 0.72 (0.64-0.78) and specificity of 0.78 (0.64-0.88). Certainty of evidence was very low.
[CONCLUSION] CMR might be more accurate than echocardiography for diagnosis of cardiac involvement in AL amyloidosis.
[METHODS] This systematic review addresses late gadolinium enhancement (LGE) on CMR and different echocardiographic findings for cardiac involvement using an acceptable reference standard. Meta-analysis reported sensitivity and specificity with 95% confidence intervals when we have ≥3 studies, or ranges for 2 studies. We assessed certainty of evidence using GRADE (Grading of Recommendations Assessment, Development, and Evaluation).
[RESULTS] Seven studies evaluated LGE, yielding pooled sensitivity and specificity of 0.95 (0.87-0.98) and 0.87 (0.76-0.94). Nineteen studies addressed echocardiography. Interventricular septum thickness showed sensitivity of 0.77 (0.69-0.84) and specificity of 0.71 (0.60-0.81). Diastolic dysfunction (grade 2-3) sensitivity was 0.71 (0.40-0.90) and specificity was 0.75 (0.64-0.84); restrictive filling pattern (grade 3) sensitivity was 0.42 (0.28-0.58) and specificity 0.89 (0.83-0.94). E/A ratio sensitivity ranged from 0.45 to 0.65, with specificity from 0.85 to 0.98. Global longitudinal strain sensitivity was 0.86 (0.65-0.95) and specificity was 0.76 (0.55-0.89). Apical sparing pattern showed sensitivity of 0.72 (0.64-0.78) and specificity of 0.78 (0.64-0.88). Certainty of evidence was very low.
[CONCLUSION] CMR might be more accurate than echocardiography for diagnosis of cardiac involvement in AL amyloidosis.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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