The hallmarks of oncogenic signaling: From pathways to resistance in cancer therapy.
1/5 보강
Oncogenic signal transduction pathways play pivotal roles in tumor progression by regulating essential cellular processes such as proliferation, survival, angiogenesis, invasion, and immune evasion.
APA
Tufail M, Gong K, et al. (2026). The hallmarks of oncogenic signaling: From pathways to resistance in cancer therapy.. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 85, 101355. https://doi.org/10.1016/j.drup.2026.101355
MLA
Tufail M, et al.. "The hallmarks of oncogenic signaling: From pathways to resistance in cancer therapy.." Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, vol. 85, 2026, pp. 101355.
PMID
41546924 ↗
Abstract 한글 요약
Oncogenic signal transduction pathways play pivotal roles in tumor progression by regulating essential cellular processes such as proliferation, survival, angiogenesis, invasion, and immune evasion. These pathways are frequently deregulated in cancer due to genetic mutations, epigenetic modifications, or microenvironmental influences. These genetic or epigenetics shifts enable cancer cells to bypass growth suppressors, resist apoptosis, and sustain uncontrolled growth. While targeted therapies have shown promise in inhibiting these signaling cascades, therapeutic resistance and tumor heterogeneity remain major obstacles. To address these limitations, emerging strategies, including combination therapies, next-generation kinase inhibitors, and immunomodulatory approaches, are being developed to overcome these challenges. This review explores the molecular mechanisms underlying oncogenic pathway activation, their contributions to hallmark cancer traits and resistance, and therapeutic advancements targeting these pathways. By understanding these signaling networks, we aim to highlight opportunities for improving cancer treatment and addressing therapeutic resistance in the evolving landscape of oncology.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Drug Resistance
- Neoplasm
- Neoplasms
- Signal Transduction
- Tumor Microenvironment
- Molecular Targeted Therapy
- Antineoplastic Agents
- Protein Kinase Inhibitors
- Animals
- Epigenesis
- Genetic
- Neovascularization
- Pathologic
- Oncogenic signaling
- cancer resistance
- hallmarks
- therapeutic targeting
- tumor progression
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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