Cytotoxic secondary metabolites from endophytic fungus sp.: isolation and evaluation.
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
The fungus was cultivated on rice medium for three weeks, extracted with ethyl acetate, and purified by chromatographic techniques, yielding two compounds identified as 19,20-epoxycytochalasin C () and ergosterol () based on NMR and FT-IR …
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
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O · Outcome 결과 / 결론
Notably, this is the first report of the chemical characterisation of sp. associated with
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This study aimed to isolate secondary metabolites produced by the endophytic fungus sp.
APA
Riga R, Vanesa A, et al. (2026). Cytotoxic secondary metabolites from endophytic fungus sp.: isolation and evaluation.. Natural product research, 1-7. https://doi.org/10.1080/14786419.2026.2643753
MLA
Riga R, et al.. "Cytotoxic secondary metabolites from endophytic fungus sp.: isolation and evaluation.." Natural product research, 2026, pp. 1-7.
PMID
41823089 ↗
Abstract 한글 요약
This study aimed to isolate secondary metabolites produced by the endophytic fungus sp. derived from and to evaluate their cytotoxic potential using and methods. The fungus was cultivated on rice medium for three weeks, extracted with ethyl acetate, and purified by chromatographic techniques, yielding two compounds identified as 19,20-epoxycytochalasin C () and ergosterol () based on NMR and FT-IR analyses. Both compounds exhibited cytotoxicity against MCF-7 breast cancer cells, with IC values of 38.4 and 45.7 μM, respectively. Molecular docking against the HER2 protein supported the results, showing binding free energies of -8.023 and -7.310 kcal/mol for compounds and , respectively. These findings suggest that both metabolites possess significant anticancer potential, particularly as candidate anticancer compounds against MCF-7 cancer cells. Notably, this is the first report of the chemical characterisation of sp. associated with
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