Diagnostic and Prognostic Biomarkers for Barrett's Esophagus.
The increasing burden of esophageal adenocarcinoma (EAC) has driven efforts to improve early detection and risk stratification.
APA
Wang F, Kahn A, et al. (2026). Diagnostic and Prognostic Biomarkers for Barrett's Esophagus.. Gastroenterology clinics of North America, 55(1), 1-19. https://doi.org/10.1016/j.gtc.2025.09.001
MLA
Wang F, et al.. "Diagnostic and Prognostic Biomarkers for Barrett's Esophagus.." Gastroenterology clinics of North America, vol. 55, no. 1, 2026, pp. 1-19.
PMID
41581944
Abstract
The increasing burden of esophageal adenocarcinoma (EAC) has driven efforts to improve early detection and risk stratification. Barrett's esophagus (BE), the only known precursor to EAC, presents an opportunity for screening and surveillance. This article highlights major advances in molecular biomarkers for BE, such as the Cytosponge-TFF3 test, methylated DNA markers, p53, aneuploidy, and other emerging biomarkers. Their integration into clinical practice may transform esophageal cancer detection and prevention by enabling precision screening and surveillance and by broadening access to care.
MeSH Terms
Humans; Barrett Esophagus; Esophageal Neoplasms; Prognosis; Adenocarcinoma; Biomarkers, Tumor; DNA Methylation; Precancerous Conditions; Biomarkers; Early Detection of Cancer; Aneuploidy
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