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Microbial metabolites: messengers in the gut-X axis.

Trends in endocrinology and metabolism: TEM 2026 Vol.37(3) p. 183-185

Fu M, Zhao Y, Jia D

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Microbes can extensively regulate the physiological or pathological processes of host organs by secreting metabolites.

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BibTeX ↓ RIS ↓
APA Fu M, Zhao Y, Jia D (2026). Microbial metabolites: messengers in the gut-X axis.. Trends in endocrinology and metabolism: TEM, 37(3), 183-185. https://doi.org/10.1016/j.tem.2026.01.002
MLA Fu M, et al.. "Microbial metabolites: messengers in the gut-X axis.." Trends in endocrinology and metabolism: TEM, vol. 37, no. 3, 2026, pp. 183-185.
PMID 41720740
DOI 10.1016/j.tem.2026.01.002

Abstract

Microbes can extensively regulate the physiological or pathological processes of host organs by secreting metabolites. Recently, Zhang et al. demonstrated that ectopic Catenibacterium mitsuokai could secrete quinolinic acid, activating the TIE2/PI3K/AKT pathway to drive hepatocellular carcinoma. These findings offer new insights into the microbial metabolite-target organ axis.

MeSH Terms

Humans; Gastrointestinal Microbiome; Animals; Liver Neoplasms; Carcinoma, Hepatocellular; Signal Transduction

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