Evolving paradigms in targeting FLT3 for acute myeloid leukemia therapy.
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FLT3 mutations drive acute myeloid leukemia (AML) progression through aberrant signaling, making FLT3 inhibition a key therapeutic strategy.
APA
Thapa R, Shrestha J, Paudel KR (2026). Evolving paradigms in targeting FLT3 for acute myeloid leukemia therapy.. Trends in pharmacological sciences, 47(3), 244-247. https://doi.org/10.1016/j.tips.2026.01.009
MLA
Thapa R, et al.. "Evolving paradigms in targeting FLT3 for acute myeloid leukemia therapy.." Trends in pharmacological sciences, vol. 47, no. 3, 2026, pp. 244-247.
PMID
41735133 ↗
Abstract 한글 요약
FLT3 mutations drive acute myeloid leukemia (AML) progression through aberrant signaling, making FLT3 inhibition a key therapeutic strategy. Current inhibitors show efficacy, yet resistance and toxicity remain challenges. Emerging approaches, including selective inhibitors, proteolysis-targeting chimeras, and protein degraders, offer enhanced potency, sustained suppression, and combinatorial potential, representing a precision-based advancement in AML treatment.
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