Regulatory role of protein tyrosine phosphatases in hematopoiesis and leukemogenesis.
1/5 보강
Protein tyrosine phosphatases (PTPs), pivotal regulators of tyrosine phosphorylation dynamics, orchestrate cellular signaling networks to govern fundamental processes such as hematopoietic stem cell (
APA
Wang X, Guan Y, et al. (2026). Regulatory role of protein tyrosine phosphatases in hematopoiesis and leukemogenesis.. Experimental and molecular pathology, 145, 105033. https://doi.org/10.1016/j.yexmp.2026.105033
MLA
Wang X, et al.. "Regulatory role of protein tyrosine phosphatases in hematopoiesis and leukemogenesis.." Experimental and molecular pathology, vol. 145, 2026, pp. 105033.
PMID
41775133 ↗
Abstract 한글 요약
Protein tyrosine phosphatases (PTPs), pivotal regulators of tyrosine phosphorylation dynamics, orchestrate cellular signaling networks to govern fundamental processes such as hematopoietic stem cell (HSC) quiescence, proliferation, and stress responses. Dysregulation of PTPs disrupts tyrosine phosphorylation homeostasis, culminating in HSC dysfunction, malignant transformation and leukemogenesis through aberrant activation of oncogenic pathways. This review summarizes the recent advances in understanding PTP-mediated mechanisms underlying HSC maintenance and leukemogenesis, with a focus on their dual roles as tumor suppressors and context-dependent oncogenic drivers. It could help explore the molecular mechanism of normal hematopoietic homeostasis and provide potential therapeutic targets of the related blood diseases.
🏷️ 키워드 / MeSH
같은 제1저자의 인용 많은 논문 (5)
- The Pendulum Movement of Orbital Fat and Retro-Orbicularis Oculi Fat: A New Strategy for Correction of Sunken Eyelid Deformity in Revision Upper Blepharoplasty for Asian Patients.
- Lifting the midface using a hyaluronic acid filler with lidocaine: A randomized multi-center study in a Chinese population.
- Study on the Effects of Estradiol in Staphylococcus epidermidis Device-Related Capsule Formation.
- Lipid Droplet-Targeted Biomimetic Liposomes Potentiate Chemo-Ferroptosis Therapy in Leukemia.
- An unprecedented potent inhibitor of MV4-11 cells: investigations into the mechanism of action beyond FLT3 inhibition.