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Rare Ectopic Presentation of an Intrasphenoidal Rathke's Cleft Cyst - Case Report and Literature Review.

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Neurology India 2026 Vol.74(2) p. 298-301
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Sattar MOA, Buckson EA, Ndlovu B, Mpanza MN, Khohomela R, Bayat Z, Daya R, Ouma JR, Profyris C

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Rathke's cleft cysts (RCCs) typically present as intrasellar lesions, with exclusive sphenoid sinus involvement being exceptionally rare.

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APA Sattar MOA, Buckson EA, et al. (2026). Rare Ectopic Presentation of an Intrasphenoidal Rathke's Cleft Cyst - Case Report and Literature Review.. Neurology India, 74(2), 298-301. https://doi.org/10.4103/neurol-india.Neurol-India-D-25-00336
MLA Sattar MOA, et al.. "Rare Ectopic Presentation of an Intrasphenoidal Rathke's Cleft Cyst - Case Report and Literature Review.." Neurology India, vol. 74, no. 2, 2026, pp. 298-301.
PMID 41817076

Abstract

Rathke's cleft cysts (RCCs) typically present as intrasellar lesions, with exclusive sphenoid sinus involvement being exceptionally rare. We report the seventh documented case of an intrasphenoidal RCC in a 39-year-old male presenting with blurred vision and headaches. Complete resection was achieved via an endoscopic endonasal approach, and the patient remained symptom-free on follow-up. To our knowledge, this is the first report to provide a series of endoscopic images illustrating the appearance and resection technique. We review the literature on this rare entity and summarize current investigative and management paradigms.

MeSH Terms

Humans; Male; Central Nervous System Cysts; Adult; Sphenoid Sinus; Magnetic Resonance Imaging