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Neoadjuvant Therapy for Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma: Current Status, Challenges, and Future Perspectives.

Cancer medicine 2026 Vol.15(3) p. e71753

Zhou J, Guo C, Zhang M, Guo X, Wang J, Liu X, Nie P, Ma Y

원문 ↗ DOI ↗ BibTeX ↓ RIS ↓
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Gastric cancer remains a leading cause of cancer-related mortality worldwide, with locally advanced gastric/gastroesophageal junction adenocarcinoma posing significant therapeutic challenges.

🔬 핵심 임상 통계 (초록에서 자동 추출 — 원문 검증 권장)
  • 연구 설계 systematic review

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BibTeX ↓ RIS ↓
APA Zhou J, Guo C, et al. (2026). Neoadjuvant Therapy for Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma: Current Status, Challenges, and Future Perspectives.. Cancer medicine, 15(3), e71753. https://doi.org/10.1002/cam4.71753
MLA Zhou J, et al.. "Neoadjuvant Therapy for Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma: Current Status, Challenges, and Future Perspectives.." Cancer medicine, vol. 15, no. 3, 2026, pp. e71753.
PMID 41876949
DOI 10.1002/cam4.71753

Abstract

Gastric cancer remains a leading cause of cancer-related mortality worldwide, with locally advanced gastric/gastroesophageal junction adenocarcinoma posing significant therapeutic challenges. Neoadjuvant therapy has emerged as a critical strategy to improve surgical outcomes and long-term survival by reducing tumor burden and eradicating micrometastases. This systematic review integrates evidence from more than 100 clinical trials and 20 meta-analyses published in recent years. It focuses on new advances in neoadjuvant therapies for gastric cancer, including chemotherapy, radiotherapy, immunotherapy, and targeted therapies, while highlighting emerging combination strategies and unresolved clinical dilemmas.

MeSH Terms

Humans; Neoadjuvant Therapy; Stomach Neoplasms; Esophagogastric Junction; Adenocarcinoma; Esophageal Neoplasms

같은 제1저자의 인용 많은 논문 (5)