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PM-modulated targets and miRNAs associated with lung cancer and injury are protected by natural products.

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Environmental pollution (Barking, Essex : 1987) 2026 Vol.393() p. 127680
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Chuang YT, Yen CY, Liu W, Chang FR, Tsai YH, Chan WH, Chien TM, Chang HW

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Particulate matter 2.5 (PM) is a ubiquitous air pollutant in both outdoor and indoor environments globally.

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APA Chuang YT, Yen CY, et al. (2026). PM-modulated targets and miRNAs associated with lung cancer and injury are protected by natural products.. Environmental pollution (Barking, Essex : 1987), 393, 127680. https://doi.org/10.1016/j.envpol.2026.127680
MLA Chuang YT, et al.. "PM-modulated targets and miRNAs associated with lung cancer and injury are protected by natural products.." Environmental pollution (Barking, Essex : 1987), vol. 393, 2026, pp. 127680.
PMID 41547393

Abstract

Particulate matter 2.5 (PM) is a ubiquitous air pollutant in both outdoor and indoor environments globally. Attenuating PM toxicity with natural products has benefits for health. Most PM-modulated targets and miRNAs have been reported in a simplified manner without interconnections to their counteractive natural products. In this review, the target-target interaction in PM studies is explored using the bioinformatic STRING database. miRNAs and natural products that regulate these PM-modulated targets are retrieved from Google Scholar and integrated into the STRING network. Moreover, an interconnection is established for PM-counteracting natural products, PM-modulated miRNAs, and targets. In conclusion, this review highlights the interconnected roles of attenuating PM toxicity by connecting natural products, miRNAs, and targets.

MeSH Terms

Particulate Matter; MicroRNAs; Air Pollutants; Humans; Lung Neoplasms; Biological Products

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