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Low-dose DOX-polygodial nanosystem modulates the CD47/CALR axis for safer triple negative breast cancer treatment.

1/5 보강
Nanoscale advances 2026 Vol.8(7) p. 2333-2350
Retraction 확인
출처
PubMed DOI PMC

PICO 자동 추출 (휴리스틱, conf 3/4)

유사 논문
P · Population 대상 환자/모집단
25 patients compared to normal tissues and investigated their role in chemoresistance at sublethal drug doses.
I · Intervention 중재 / 시술
doxorubicin (DOX), polygodial (PG), or both, and CD47/CALR expression was analyzed at sublethal concentrations determined MTT assay
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
Combination treatment of (DOX + PG), as well as co-loaded NPs, significantly decreased CD47 and CALR levels, reversing CD47 and CALR elevation that acts as a surrogate immunosurveillance marker and enhancing the CALR/CD47 surface expression ratio. These findings suggest a promising strategy for further examination and dose optimization studies for metastasis inhibition and as maintenance therapy.

Emara HM, Youness RA, Manie TM, Abdelnaser A, Allam NK

📖 무료 전문 🟢 PMC 전문 PMC12959604
PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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