Quality of life trajectory in breast cancer survivors: A longitudinal, two-year post treatment follow-up study.

[BACKGROUND] Advances in breast cancer treatment have improved survival, making Quality of Life (QOL) a critical endpoint. This study examines longitudinal QOL in Indian breast cancer survivors using the Functional Assessment of Cancer Therapy for Breast (FACT-B) questionnaire.

[METHODS] A longitudinal cohort study followed 338 women with curable breast cancer, assessing QOL at baseline (before treatment), 3 months, 6 months, 12 months, and 24 months post-treatment. The FACT-B provided total and subscale scores (Physical, Social, Emotional, Functional, and Breast-specific well-being).

[RESULTS] Of 338 patients, 63 (18.64%) completed all assessments up to 24 months, and 68 (20.12%) completed up to 12 months. QOL decreased significantly at 3 months post-treatment (mean 74.98 vs. 85.6 at baseline, p < 0.001), remained below baseline at 6 months (79.34, p < 0.001), returned to baseline by 12 months (87.94, p = 0.147), and improved significantly by 24 months (110.92, p < 0.001). Physical and Functional well-being showed early declines, Social and Emotional well-being remained stable or improved, and Breast-specific well-being remained low, reflecting body image concerns.

[CONCLUSION] The U-shaped QOL trajectory highlights the need for interventions at 3-6 months post-treatment, particularly for body image and physical function. These findings provide a foundation for targeted supportive care in Indian breast cancer survivors.