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TBCRC 035: randomized phase II pharmacodynamic study of standard and reduced-dose palbociclib with endocrine therapy in hormone receptor (HR)-positive previously treated metastatic breast cancer.

2/5 보강

ESMO open 📖 저널 OA 100% 2022~2026 2026 Vol.11(4) p. 106063 OA Advanced Breast Cancer Therapies

TL;DR Palbociclib 100 mg was associated with a reduced incidence of ≥grade 3 neutropenia and while PFS was numerically lower at 100 mg, the difference was not statistically significant and was limited by sample size and complicated by varying degrees of pre-treatment.

PICO 자동 추출 (휴리스틱, conf 3/4)

유사 논문

P · Population 대상 환자/모집단

환자: a median of 3 prior treatment lines (range 0-6) were enrolled; 36 received 100 mg and 34 received 125 mg

I · Intervention 중재 / 시술

100 mg and 34 received 125 mg

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

Analysis of skin and tumor pRb or Ki-67 demonstrated robust molecular response at both doses. PIK3CA and TP53 mutations and higher baseline Ki-67 were associated with inferior clinical outcome.

OpenAlex 토픽 · Advanced Breast Cancer Therapies Breast Cancer Treatment Studies Cancer-related Molecular Pathways

Jacob S, Mayer EL, Kacik N, Storniolo AM, Isaacs C, Mayer I

📖 무료 전문 🟢 PMC 전문 PMC12995829 🔓 OA PDF oa

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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