Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression.
2/5 보강
TL;DR
The existing evidence regarding mitochondrial RNA modifications and their significance in cancer progression is evaluated and the potential of these modifications as promising targets for both preventative strategies and early diagnostic screening is investigated.
OpenAlex 토픽 ·
RNA modifications and cancer
Mitochondrial Function and Pathology
Metalloenzymes and iron-sulfur proteins
The existing evidence regarding mitochondrial RNA modifications and their significance in cancer progression is evaluated and the potential of these modifications as promising targets for both prevent
APA
Lingzhi Wang, Tao Yang, et al. (2026). Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression.. Acta pharmacologica Sinica, 47(4), 801-810. https://doi.org/10.1038/s41401-025-01682-9
MLA
Lingzhi Wang, et al.. "Roles and related underlying mechanisms of mitochondrial RNA modification in cancer progression.." Acta pharmacologica Sinica, vol. 47, no. 4, 2026, pp. 801-810.
PMID
41326810 ↗
Abstract 한글 요약
Mitochondrial RNA modifications refer to modifications that occur across various RNA species within the mitochondria. While the incidence of such modifications is lower than that in the cytoplasm, substantial evidence highlights their pivotal role in facilitating mitochondrial gene expression and precise protein synthesis. Emerging research suggests that these mitochondrial RNA modifications are also significantly involved in the progression of cancer. In this review, we first delve into the diversity of mitochondrial RNA modifications, their potential sites of occurrence, and the enzymes involved in these processes. We evaluate the existing evidence regarding mitochondrial RNA modifications and their significance in cancer progression and investigate the potential of these modifications as promising targets for both preventative strategies and early diagnostic screening. Finally, we deliberate on the trajectory of mitochondrial RNA modifications in the context of cancer progression and how these RNA modifications might pave the way for novel diagnostic and therapeutic approaches for preventive medicine.
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