Sodium alginate functionalized nickel ferrite nanocomposites: synthesis, physicochemical characterization, and evaluation of antibacterial, anticancer, and biocompatibility properties.
1/5 보강
The rise of multidrug-resistant bacteria and the need for effective therapies against breast cancer highlight the demand for multifunctional nanomaterials with high biocompatibility.
APA
Pattnaik S, Shashikala AR, et al. (2026). Sodium alginate functionalized nickel ferrite nanocomposites: synthesis, physicochemical characterization, and evaluation of antibacterial, anticancer, and biocompatibility properties.. International journal of biological macromolecules, 359, 151717. https://doi.org/10.1016/j.ijbiomac.2026.151717
MLA
Pattnaik S, et al.. "Sodium alginate functionalized nickel ferrite nanocomposites: synthesis, physicochemical characterization, and evaluation of antibacterial, anticancer, and biocompatibility properties.." International journal of biological macromolecules, vol. 359, 2026, pp. 151717.
PMID
41951080 ↗
Abstract 한글 요약
The rise of multidrug-resistant bacteria and the need for effective therapies against breast cancer highlight the demand for multifunctional nanomaterials with high biocompatibility. In this study, Nickel ferrite (NiFe₂O₄) and sodium alginate functionalized NiFe₂O₄ nanocomposites (NiFe₂O₄-SA) were synthesized via a green co-precipitation method. X-ray diffraction confirmed a cubic spinel structure, and transmission electron microscopy revealed quasi-spherical nanoparticles with sizes of 15-25 nm and uniform alginate coating. UV-Vis analysis showed a reduction in band gap from 4.44 eV to 3.13 eV, while photoluminescence spectra indicated enhanced charge carrier separation. NiFe₂O₄-SA exhibited strong antibacterial activity against Gram-negative pathogens (Klebsiella pneumoniae, Escherichia coli, Shigella dysenteriae, Pseudomonas aeruginosa, and Proteus vulgaris), with membrane disruption confirmed by microscopy. Cytotoxicity studies on MCF-7 breast cancer cells demonstrated dose-dependent inhibition with an IC₅₀ of 11.9 μg/mL, and zebrafish embryo assays confirmed excellent biocompatibility for NiFe₂O₄-SA. These findings highlight NiFe₂O₄-SA nanocomposites as promising multifunctional nanomaterials for therapeutic and biomedical applications.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Nickel
- Anti-Bacterial Agents
- Alginates
- Humans
- Nanocomposites
- Antineoplastic Agents
- Ferric Compounds
- Animals
- Biocompatible Materials
- Zebrafish
- MCF-7 Cells
- Microbial Sensitivity Tests
- Chemical Phenomena
- Antibacterial
- Biocompatibility
- Breast cancer
- Nickel ferrite
- Sodium alginate coated nickel ferrite
- Zebra fish studies
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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