SCF-FBXO31 E3 ubiquitin ligase in cancer: Molecular insights and clinical implications.
2/5 보강
TL;DR
Understanding the nuanced biology of FBXO31 is crucial for unravelling its role in tumorigenesis and advancing future therapeutic strategies.
OpenAlex 토픽 ·
Ubiquitin and proteasome pathways
Microtubule and mitosis dynamics
Cell death mechanisms and regulation
Understanding the nuanced biology of FBXO31 is crucial for unravelling its role in tumorigenesis and advancing future therapeutic strategies.
APA
Osheen Sahay, Abhayananda Behera, et al. (2026). SCF-FBXO31 E3 ubiquitin ligase in cancer: Molecular insights and clinical implications.. Biochimica et biophysica acta. Reviews on cancer, 1881(2), 189534. https://doi.org/10.1016/j.bbcan.2026.189534
MLA
Osheen Sahay, et al.. "SCF-FBXO31 E3 ubiquitin ligase in cancer: Molecular insights and clinical implications.." Biochimica et biophysica acta. Reviews on cancer, vol. 1881, no. 2, 2026, pp. 189534.
PMID
41554415 ↗
Abstract 한글 요약
F-box only protein 31 (FBXO31), a substrate adapter of SKP1-Cullin1-F-box (SCF) E3 ubiquitin ligase, was first identified as a candidate tumor suppressor in breast cancer due to its role in inducing senescence. Over the past two decades, FBXO31 has emerged as a crucial regulator in several human cancers, where it promotes the proteasomal degradation of various oncoproteins. FBXO31 plays a crucial role in regulating the cell cycle to maintain genomic integrity and inhibits processes such as epithelial-to-mesenchymal transition (EMT), invasion, and metastasis. This review examines the molecular mechanisms underlying the potent tumor-suppressive functions of FBXO31 in diverse human cancers. We also discuss the underlying causes of FBXO31 deregulation in cancer, providing insights into the intricate regulatory networks governing its expression. Additionally, we also examine the unexpected oncogenic functions of FBXO31 in certain cellular contexts. Finally, we highlight the clinical potential of FBXO31 in human malignancies, discussing its implications as both a biomarker and a therapeutic target. In conclusion, understanding the nuanced biology of FBXO31 is crucial for unravelling its role in tumorigenesis and advancing future therapeutic strategies.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Neoplasms
- Tumor Suppressor Proteins
- Epithelial-Mesenchymal Transition
- F-Box Proteins
- Muscle Proteins
- SKP Cullin F-Box Protein Ligases
- Animals
- Gene Expression Regulation
- Neoplastic
- Ubiquitin-Protein Ligases
- Cancer
- Cell cycle
- F-box proteins
- FBXO31
- Genome integrity
- Prognostic biomarker
- Proteasomal degradation
- Ubiquitination
🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
- A Phase I Study of Hydroxychloroquine and Suba-Itraconazole in Men with Biochemical Relapse of Prostate Cancer (HITMAN-PC): Dose Escalation Results.
- Self-management of male urinary symptoms: qualitative findings from a primary care trial.
- Clinical and Liquid Biomarkers of 20-Year Prostate Cancer Risk in Men Aged 45 to 70 Years.
- Diagnostic accuracy of Ga-PSMA PET/CT versus multiparametric MRI for preoperative pelvic invasion in the patients with prostate cancer.
- Comprehensive analysis of androgen receptor splice variant target gene expression in prostate cancer.
- Clinical Presentation and Outcomes of Patients Undergoing Surgery for Thyroid Cancer.