Management of adverse events associated with TROP2-targeted antibody-drug conjugates in cancer patients.
Antibody-drug conjugates (ADCs) constitute an innovative category of anti-tumor therapeutics that selectively deliver cytotoxins to tumor cells, improving efficacy and reducing toxicity in comparison
APA
He Z, Luo Z, et al. (2026). Management of adverse events associated with TROP2-targeted antibody-drug conjugates in cancer patients.. Critical reviews in oncology/hematology, 220, 105153. https://doi.org/10.1016/j.critrevonc.2026.105153
MLA
He Z, et al.. "Management of adverse events associated with TROP2-targeted antibody-drug conjugates in cancer patients.." Critical reviews in oncology/hematology, vol. 220, 2026, pp. 105153.
PMID
41587589
Abstract
Antibody-drug conjugates (ADCs) constitute an innovative category of anti-tumor therapeutics that selectively deliver cytotoxins to tumor cells, improving efficacy and reducing toxicity in comparison to systemic therapy. TROP2 serves as a significant target for ADCs in cancer detection and treatment. TROP2-targeted ADCs have shown promising efficacy in cancer therapy. However, it is essential to monitor expected adverse effects to ensure the anti-tumor efficacy and safety. This review clarifies the mechanisms and toxicological profiles of TROP2-targeted medicines based on clinical trials and recommendations, with the aim of providing solutions for the prevention, detection, and management of related adverse events.
MeSH Terms
Humans; Immunoconjugates; Neoplasms; Antigens, Neoplasm; Cell Adhesion Molecules; Antineoplastic Agents; Drug-Related Side Effects and Adverse Reactions
같은 제1저자의 인용 많은 논문 (5)
- A Case of Relapsed/Refractory Primary Central Nervous System B-Cell Lymphoma with Renal Insufficiency Successfully Treated with Linperlisib.
- Artemisinin sensitizes triple negative breast cancer to immune checkpoint therapy through suppressing KEAP1-mediated PD-L1 degradation.
- The effectiveness and safety of Yi Guan Jian decoction in the treatment of primary liver cancer: A systematic review and meta-analysis of randomized controlled trials.
- The Impact of Dosage and Injection Site on Type A Botulinum Toxin Treatment for Oral Commissure Ptosis: A Prospective Study.
- Quinoline/Naphthalene-Embedded PSMA Probes for Precise PET Imaging with Minimized Undesired Retention.