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Discovery of Potent and Brain-Penetrable Tubulin Inhibitors that Effectively Suppress Breast Cancer Brain Metastasis.

3/5 보강

Molecular cancer therapeutics 📖 저널 OA 54.2% 2022~2026 2026 Vol.25(4) p. 584-598 cited 1 OA Brain Metastases and Treatment

TL;DR New innovative colchicine binding site inhibitors targeting tubulin, SB-216 and SP-1-39, that show potent preclinical efficacy against brain and extracranial metastases in BCBM models are developed, filling a critical gap in TNBC management by offering targeted treatments that can cross the BBB and combat chemorefractory disease.

PICO 자동 추출 (휴리스틱, conf 2/4)

유사 논문

P · Population 대상 환자/모집단

환자: metastatic breast cancer develop BCBM, with the highest incidence in patients with aggressive molecular subtypes, including triple-negative breast cancer (TNBC)

I · Intervention 중재 / 시술

추출되지 않음

C · Comparison 대조 / 비교

추출되지 않음

O · Outcome 결과 / 결론

In a taxane-refractory patient-derived TNBC model, SP-1-39 therapy markedly reduced brain and extracranial tumor burden. Together, these results highlight the promising therapeutic potential of SB-216 and SP-1-39 in treating taxane-sensitive or -resistant BCBM, filling a critical gap in TNBC management by offering targeted treatments that can cross the BBB and combat chemorefractory disease.

OpenAlex 토픽 · Brain Metastases and Treatment Lung Cancer Research Studies Barrier Structure and Function Studies

Krutilina RI, Adeleye KL, Playa HC, Pochampally S, Banjeree S, Oluwalana D

📖 무료 전문 🟢 PMC 전문 PMC12830028 🔓 OA PDF oa

PubMed ↗ DOI ↗ BibTeX ↓ RIS ↓

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