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Application of artificial intelligence in colonoscopy imaging for polyp analysis-A systematic review.

Computer methods and programs in biomedicine 2026 Vol.277() p. 109239

Amirmohammadi E, Shalbaf A, Esteki A, Sadeghi A, Moghadam AR, Moghtaderi M, Moghadam PK

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The colon is a major component of the digestive system, so early detection of colorectal polyps is essential in preventing colorectal cancer, which is a leading cause of cancer-related death worldwide

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BibTeX ↓ RIS ↓
APA Amirmohammadi E, Shalbaf A, et al. (2026). Application of artificial intelligence in colonoscopy imaging for polyp analysis-A systematic review.. Computer methods and programs in biomedicine, 277, 109239. https://doi.org/10.1016/j.cmpb.2026.109239
MLA Amirmohammadi E, et al.. "Application of artificial intelligence in colonoscopy imaging for polyp analysis-A systematic review.." Computer methods and programs in biomedicine, vol. 277, 2026, pp. 109239.
PMID 41621228

Abstract

The colon is a major component of the digestive system, so early detection of colorectal polyps is essential in preventing colorectal cancer, which is a leading cause of cancer-related death worldwide. While colonoscopy remains the gold standard for polyp detection, its diagnostic accuracy is highly operator-dependent. Recent advances in Deep Learning (DL), a branch of Artificial Intelligence (AI), have shown substantial potential to improve colonoscopy image analysis by enhancing the accuracy, consistency, and objectivity of polyp detection, segmentation, and classification. Artificial intelligence-based systems have significantly reduced inter-observer variability and increased diagnostic efficiency, ultimately transforming the landscape of colorectal lesion assessment. This survey provides a comprehensive and critical analysis of the current status of deep learning applications in colorectal polyp analysis. We systematically review state-of-the-art methodologies across various DL architectures-including Convolutional Neural Networks (CNNs), transformer-based models, and hybrid approaches-and examine their performance on publicly available benchmark datasets. Additionally, we highlight the strengths and limitations of existing techniques, explore the clinical relevance of AI-assisted tools, and identify prevailing challenges such as data imbalance, real-time deployment, and generalizability across diverse populations and colonoscopy devices. By consolidating key advances and outlining future research directions, this review aims to serve as a valuable resource for researchers, clinicians, and developers seeking to leverage deep learning to enhance colorectal polyp detection, diagnosis, and clinical decision-making.

MeSH Terms

Humans; Colonoscopy; Artificial Intelligence; Colonic Polyps; Deep Learning; Neural Networks, Computer; Colorectal Neoplasms; Image Processing, Computer-Assisted; Image Interpretation, Computer-Assisted