Sensitivity and specificity of ultrasonic assessment of axillary lymph node for breast cancer: A diagnostic meta-analysis.
메타분석
1/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
9886 patients met the inclusion criteria.
I · Intervention 중재 / 시술
추출되지 않음
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[IMPLICATIONS FOR PRACTICE] Axillary ultrasound can aid early detection of nodal metastasis but should not replace biopsy confirmation. Integrating AUS with tissue sampling enhances diagnostic accuracy and surgical planning.
[INTRODUCTION] Breast cancer is among the worldwide list of commonly diagnosed cancers and one of the leading causes of highest mortality rate worldwide.
- 연구 설계 meta-analysis
APA
Saeed S, Usama M, et al. (2026). Sensitivity and specificity of ultrasonic assessment of axillary lymph node for breast cancer: A diagnostic meta-analysis.. Radiography (London, England : 1995), 32(3), 103330. https://doi.org/10.1016/j.radi.2026.103330
MLA
Saeed S, et al.. "Sensitivity and specificity of ultrasonic assessment of axillary lymph node for breast cancer: A diagnostic meta-analysis.." Radiography (London, England : 1995), vol. 32, no. 3, 2026, pp. 103330.
PMID
41650788 ↗
Abstract 한글 요약
[INTRODUCTION] Breast cancer is among the worldwide list of commonly diagnosed cancers and one of the leading causes of highest mortality rate worldwide. Prompt detection facilitates timely and accurate diagnostic investigations required for determining the course of disease and managing it. This meta-analysis aimed to evaluate the sensitivity, specificity, and diagnostic reliability of Axillary Ultrasound (AUS) in detecting axillary lymph node involvement in breast cancer patients.
[METHODS] On May 17, 2024, a systematic search was performed in PubMed and Embase in accordance with the inclusion criteria of the study. The index test consisted of ultrasonographic diagnostic methods and Fine Needle Aspiration (FNA)-guided Axillary Ultrasound, whereas the reference standard was Sentinel Lymph Node Biopsy (SLNB).
[RESULTS] Out of 4874 studies, 19 studies encompassing 9886 patients met the inclusion criteria. The summary sensitivity and specificity of axillary ultrasound were 65.25 % and 87.18 % before outlier adjustment; and 62.20 % and 88.43 % after outlier adjustment respectively. The diagnostic odds ratio (DOR) was 0.27 before outlier and 0.20 after outlier assessment indicating moderate diagnostic performance. Subgroup analysis revealed significant variation in specificity based on risk of bias but not in sensitivity or DOR. The hierarchal Summary receiver operator curve (SROC) demonstrated moderate sensitivity and high specificity in heterogenous studies.
[CONCLUSION] Axillary ultrasound demonstrates high specificity but moderate sensitivity in detecting nodal metastasis in breast cancer. While useful as a preliminary diagnostic tool, it should not replace biopsy-based confirmation. Combining AUS with tissue sampling or advanced imaging may improve preoperative staging accuracy.
[IMPLICATIONS FOR PRACTICE] Axillary ultrasound can aid early detection of nodal metastasis but should not replace biopsy confirmation. Integrating AUS with tissue sampling enhances diagnostic accuracy and surgical planning.
[METHODS] On May 17, 2024, a systematic search was performed in PubMed and Embase in accordance with the inclusion criteria of the study. The index test consisted of ultrasonographic diagnostic methods and Fine Needle Aspiration (FNA)-guided Axillary Ultrasound, whereas the reference standard was Sentinel Lymph Node Biopsy (SLNB).
[RESULTS] Out of 4874 studies, 19 studies encompassing 9886 patients met the inclusion criteria. The summary sensitivity and specificity of axillary ultrasound were 65.25 % and 87.18 % before outlier adjustment; and 62.20 % and 88.43 % after outlier adjustment respectively. The diagnostic odds ratio (DOR) was 0.27 before outlier and 0.20 after outlier assessment indicating moderate diagnostic performance. Subgroup analysis revealed significant variation in specificity based on risk of bias but not in sensitivity or DOR. The hierarchal Summary receiver operator curve (SROC) demonstrated moderate sensitivity and high specificity in heterogenous studies.
[CONCLUSION] Axillary ultrasound demonstrates high specificity but moderate sensitivity in detecting nodal metastasis in breast cancer. While useful as a preliminary diagnostic tool, it should not replace biopsy-based confirmation. Combining AUS with tissue sampling or advanced imaging may improve preoperative staging accuracy.
[IMPLICATIONS FOR PRACTICE] Axillary ultrasound can aid early detection of nodal metastasis but should not replace biopsy confirmation. Integrating AUS with tissue sampling enhances diagnostic accuracy and surgical planning.
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