The rise of bispecific T-cell engager (BsTCE) antibodies: a potentially game-changing approach for breast cancer therapy?
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OpenAlex 토픽 ·
Monoclonal and Polyclonal Antibodies Research
CAR-T cell therapy research
HER2/EGFR in Cancer Research
Over the past decade, there has been exponential growth in the development of bispecific T-cell engager (BsTCE) antibodies, along with their immunotherapeutic applications in oncology.
APA
Pravin U Gudavalekar, Prakash Y. Khandave, et al. (2026). The rise of bispecific T-cell engager (BsTCE) antibodies: a potentially game-changing approach for breast cancer therapy?. Drug discovery today, 31(3), 104670. https://doi.org/10.1016/j.drudis.2026.104670
MLA
Pravin U Gudavalekar, et al.. "The rise of bispecific T-cell engager (BsTCE) antibodies: a potentially game-changing approach for breast cancer therapy?." Drug discovery today, vol. 31, no. 3, 2026, pp. 104670.
PMID
41967765 ↗
Abstract 한글 요약
Over the past decade, there has been exponential growth in the development of bispecific T-cell engager (BsTCE) antibodies, along with their immunotherapeutic applications in oncology. BsTCEs are an emerging class of bispecific antibodies that represent a novel T-cell-based immunotherapy, altering the treatment landscape for solid tumors by introducing novel functionality that redirects T cells to tumor-associated antigens to induce tumor cell killing. In breast cancer, one of the leading causes of death worldwide, human epidermal growth factor receptor 2 (HER2) is a well-studied tumor-associated antigen, while several other emerging targets are being evaluated. This review aims to provide insights into the vital role of BsTCEs and the dire need to target emerging antigens in breast cancer, particularly for addressing ongoing challenges related to drug resistance.
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