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Glioneuronal and Neuronal Tumors in Adults: World Health Organization 2021 Imaging and Molecular Updates.

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AJNR. American journal of neuroradiology 2026 Vol.47(4) p. 867-878 OA Glioma Diagnosis and Treatment
TL;DR This review aims to highlight the key updated features of glioneuronal and neuronal tumors in adults based on the fifth edition of the WHO Classification of Central Nervous System Tumors by clinical and epidemiological presentation, imaging appearance, and pathology.
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PubMed DOI PMC OpenAlex Semantic 마지막 보강 2026-04-30
OpenAlex 토픽 · Glioma Diagnosis and Treatment Epilepsy research and treatment Neurogenesis and neuroplasticity mechanisms

Warstadt MB, Richards TJ, Shah LM, Kohler ME, Mendez JS, Malani R

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This review aims to highlight the key updated features of glioneuronal and neuronal tumors in adults based on the fifth edition of the WHO Classification of Central Nervous System Tumors by clinical a

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APA Melissa B. Warstadt, Tyler Richards, et al. (2026). Glioneuronal and Neuronal Tumors in Adults: World Health Organization 2021 Imaging and Molecular Updates.. AJNR. American journal of neuroradiology, 47(4), 867-878. https://doi.org/10.3174/ajnr.A9102
MLA Melissa B. Warstadt, et al.. "Glioneuronal and Neuronal Tumors in Adults: World Health Organization 2021 Imaging and Molecular Updates.." AJNR. American journal of neuroradiology, vol. 47, no. 4, 2026, pp. 867-878.
PMID 41238398 ↗
DOI 10.3174/ajnr.A9102

Abstract

Glioneuronal and neuronal tumors are defined histologically by the presence of mixed glial and neuronal elements in the case of glioneuronal tumors, and by neuronal elements in the case of neuronal tumors. In 2021, the World Health Organization (WHO) published the latest edition of a CNS tumor classification and added 3 new glioneuronal tumors, as well as further delineated histologic, immunohistochemical, and molecular markers associated with the diagnosis of these tumors. This review aims to highlight the key updated features of glioneuronal and neuronal tumors in adults based on the fifth edition of the WHO Classification of Central Nervous System Tumors by clinical and epidemiological presentation, imaging appearance, and pathology.

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