/miR-675 Axis Promotes Cancer Metastasis by Orchestrating EMT and MET Processes.

Despite substantial advances in our understanding of cancer metastasis, it remains the leading cause of mortality among cancer patients. Elucidating the molecular mechanisms that drive metastatic progression is expected to facilitate the development of more effective therapeutic strategies. Among the numerous candidates, the long non-coding RNA and its derivative miR-675 have been increasingly recognized as key regulators of metastatic dissemination in cancers of diverse tissue origins. In this review, we provide an up-to-date overview of the /miR-675 axis in metastatic progression, with particular emphasis on its involvement in the dynamic and complementary processes of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET). We also highlight the opportunity to consider the /miR-675 axis as promising biomarkers and potential therapeutic targets.