Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity.
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OpenAlex 토픽 ·
Cancer Immunotherapy and Biomarkers
Immune cells in cancer
Cancer, Hypoxia, and Metabolism
Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved.
APA
Naomi Iris van den Berg, Matouš Elphick, et al. (2026). Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity.. Cancer cell, 44(4), 689-695. https://doi.org/10.1016/j.ccell.2026.03.002
MLA
Naomi Iris van den Berg, et al.. "Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity.." Cancer cell, vol. 44, no. 4, 2026, pp. 689-695.
PMID
41895278 ↗
Abstract 한글 요약
Why the link between immune infiltration and tumor control varies so strongly across tissues remains unresolved. We propose the "immunometabolic gatekeeping" framework, whereby tissue-intrinsic metabolic activity and waste-handling capacity shape anti-tumour immunity. In high-flux tissues, metabolic stress impairs immune surveillance, decoupling infiltration from control and allowing tumor outgrowth. This framework explains cancer paradoxes-including T cell prognostic heterogeneity, hereditary and pediatric tumor tropisms, sex-biased tumor incidence, and cancer-resistant species-and suggests metabolism-aware strategies for cancer prevention and immunotherapy.
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