EBV-positive CD8 + peripheral T-cell lymphoma in the post-transplant setting: case report and review of the literature.

Post-transplant T-cell lymphomas are an infrequent complication in the setting of prolonged immunosuppression and are typically Epstein-Barr virus (EBV) negative. Herein, we present a case of a 23-year-old individual with history of a kidney transplant who developed multifocal lymphadenopathy and osseous lesions. Biopsy of a spinal lesion demonstrated a T-cell lymphoma with diffuse EBV positivity and CD8 expression. The patient's disease was refractory to conventional chemotherapy with persistent/recurrent disease in other organ systems showing the aggressive nature of this disease and limited efficacy of standard regimens.