[Bifunctional biomaterials: An innovative strategy for synergistic bone tumor therapy and bone regeneration].

[OBJECTIVE] To review research progress of bifunctional biomaterials in the treatment of bone tumors and bone defects in recent years, aiming to provide assistance for the further research of bifunctional biomaterials.

[METHODS] A wide range of domestic and international literature on the preparation and properties of novel bifunctional biomaterials in recent years was reviewed, followed by summary and analysis. Carrier-functionalized materials, intrinsically active materials, and immune-engineered materials were summarized respectively, and discussions were conducted from aspects such as anti-tumor effects and controlled drug release.

[RESULTS] Studies have revealed that, unlike traditional biomaterials, the novel bifunctional biomaterials can effectively inhibit the recurrence of bone tumors through precise drug delivery, external field-responsive tumor killing and immunomodulatory anti-tumor effects. Meanwhile, relying on osteoconduction, osteoinduction, and tissue engineering technologies, they promote new bone formation and bone functional reconstruction in bone defect areas.

[CONCLUSION] Novel multifunctional biomaterials can inhibit bone tumor cells and promote new bone formation at the site of bone defects.