[Evolving treatment landscape of pediatric acute leukemia: integration and breakthroughs in immunotherapy and targeted therapy].
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OpenAlex 토픽 ·
CAR-T cell therapy research
Acute Lymphoblastic Leukemia research
Acute Myeloid Leukemia Research
In recent years, immunotherapy and targeted therapy are reshaping the therapeutic paradigm of pediatric acute leukemia, shifting it from a protocol-driven era toward a strategy-oriented era.
APA
Feiqiu Wen, Hui-Rong Mai (2026). [Evolving treatment landscape of pediatric acute leukemia: integration and breakthroughs in immunotherapy and targeted therapy].. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 28(4), 402-409. https://doi.org/10.7499/j.issn.1008-8830.2602085
MLA
Feiqiu Wen, et al.. "[Evolving treatment landscape of pediatric acute leukemia: integration and breakthroughs in immunotherapy and targeted therapy].." Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, vol. 28, no. 4, 2026, pp. 402-409.
PMID
42015693 ↗
Abstract 한글 요약
In recent years, immunotherapy and targeted therapy are reshaping the therapeutic paradigm of pediatric acute leukemia, shifting it from a protocol-driven era toward a strategy-oriented era. The significance is not only in improving remission rates, but also in achieving deeper measurable residual disease (MRD) clearance, enabling more precise risk stratification, reducing cumulative toxicity, and advancing standardized implementation with enhanced accessibility in real-world clinical practice. Integrating pivotal clinical studies, real-world evidence, and advances in drug approval and policy, this article proposes three core themes-deep remission, low toxicity, and high accessibility. It highlights MRD and molecular stratification as anchors for therapeutic decision-making, emphasizes optimizing combination and sequential strategies based on relapse mechanisms, and advocates strengthening long-term follow-up systems and improving access to diagnosis and treatment, aiming to shift clinical practice from efficacy improvement toward high-quality cure.
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🏷️ 같은 키워드 · 무료전문 — 이 논문 MeSH/keyword 기반
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