Understanding the Effects of Cancer-Related Factors on the Association Between Physical Activity and Quality of Life in Breast Cancer Survivors.
OpenAlex 토픽 ·
Cancer survivorship and care
Cancer-related cognitive impairment studies
Cancer Risks and Factors
[BACKGROUND] Breast cancer survivors often experience physical and mental side effects posttreatment, compromising their quality of life (QoL).
- p-value P = .003
- p-value P = .028
- 연구 설계 randomized controlled trial
APA
Erica Schleicher, W Demark-Wahnefried, et al. (2026). Understanding the Effects of Cancer-Related Factors on the Association Between Physical Activity and Quality of Life in Breast Cancer Survivors.. Journal of physical activity & health, 1-9. https://doi.org/10.1123/jpah.2025-0583
MLA
Erica Schleicher, et al.. "Understanding the Effects of Cancer-Related Factors on the Association Between Physical Activity and Quality of Life in Breast Cancer Survivors.." Journal of physical activity & health, 2026, pp. 1-9.
PMID
42019937
Abstract
[BACKGROUND] Breast cancer survivors often experience physical and mental side effects posttreatment, compromising their quality of life (QoL). The increasing number of survivors coping with long-term side effects creates public health concerns, emphasizing the need for supportive interventions. Although physical activity (PA) benefits cancer survivors, few studies examine the effect that cancer-related factors have on the relationship between PA levels and QoL among breast cancer survivors. Understanding the associations that cancer-related factors may have on the QoL response to PA is crucial for developing effective interventions.
[METHODS] Baseline data from 341 postprimary treatment breast cancer survivors enrolled in a web-based diet and/or exercise intervention randomized controlled trial were analyzed. PA measures included accelerometry and self-reported moderate to vigorous PA (MVPA). QoL was assessed using Patient-Reported Outcomes Measurement Information System (PROMIS) global QoL and EuroQOL-5D-5L questionnaires. Pearson correlation coefficient tests and multiple linear regression assessed associations between MVPA and QoL and whether cancer-related factors moderated these associations.
[RESULTS] The EuroQOL-5D-5L QoL index (and 4 out of 5 domains) showed statistically significant associations with self-reported MVPA. PROMIS physical health was correlated with both MVPA measures. Survivors > 24 months postdiagnosis had stronger associations between accelerometry-measured MVPA levels and EuroQOL-5D-5 L QoL index (β = 0.0004, P = .003). Survivors receiving hormone therapy exhibited stronger associations between self-reported MVPA levels and PROMIS-physical health QoL domain compared with those not (β = 0.0121, P = .028).
[CONCLUSION] Greater MVPA was modestly associated with better QoL, with stronger associations observed in survivors receiving hormone therapy or >24 months postdiagnosis. There are potential QoL benefits in implementing interventions immediately postdiagnosis and tailoring to treatment histories.
[METHODS] Baseline data from 341 postprimary treatment breast cancer survivors enrolled in a web-based diet and/or exercise intervention randomized controlled trial were analyzed. PA measures included accelerometry and self-reported moderate to vigorous PA (MVPA). QoL was assessed using Patient-Reported Outcomes Measurement Information System (PROMIS) global QoL and EuroQOL-5D-5L questionnaires. Pearson correlation coefficient tests and multiple linear regression assessed associations between MVPA and QoL and whether cancer-related factors moderated these associations.
[RESULTS] The EuroQOL-5D-5L QoL index (and 4 out of 5 domains) showed statistically significant associations with self-reported MVPA. PROMIS physical health was correlated with both MVPA measures. Survivors > 24 months postdiagnosis had stronger associations between accelerometry-measured MVPA levels and EuroQOL-5D-5 L QoL index (β = 0.0004, P = .003). Survivors receiving hormone therapy exhibited stronger associations between self-reported MVPA levels and PROMIS-physical health QoL domain compared with those not (β = 0.0121, P = .028).
[CONCLUSION] Greater MVPA was modestly associated with better QoL, with stronger associations observed in survivors receiving hormone therapy or >24 months postdiagnosis. There are potential QoL benefits in implementing interventions immediately postdiagnosis and tailoring to treatment histories.