Pigmented Renal Epithelioid Angiomyolipoma: A Case Report and Literature Review.
TL;DR
There is a growing need for novel and effective medical therapy for uterine fibroids, as Statins have shown broad‐reaching pleiotropic effects on uterine fibroids, potentially inhibiting growth, reducing the incidence, and alleviating the symptoms.
OpenAlex 토픽 ·
Tuberous Sclerosis Complex Research
Vascular Tumors and Angiosarcomas
Renal cell carcinoma treatment
There is a growing need for novel and effective medical therapy for uterine fibroids, as Statins have shown broad‐reaching pleiotropic effects on uterine fibroids, potentially inhibiting growth, reduc
APA
Quinn Rainer, Li Lei, Yue Sun (2026). Pigmented Renal Epithelioid Angiomyolipoma: A Case Report and Literature Review.. International journal of surgical pathology, 34(3), 735-744. https://doi.org/10.1177/10668969251382747
MLA
Quinn Rainer, et al.. "Pigmented Renal Epithelioid Angiomyolipoma: A Case Report and Literature Review.." International journal of surgical pathology, vol. 34, no. 3, 2026, pp. 735-744.
PMID
41277328
Abstract
Melanin pigmentation in epithelioid angiomyolipoma (AML), a potentially malignant and locally aggressive renal tumor, is an exceptionally rare finding. Accurate differentiation from other pigmented tumors, such as melanoma, pigmented paraganglioma, and pigmented renal cell carcinoma is essential for proper diagnosis and treatment. A retrospective review of 2 departmental archives (2000-2023) identified 2 pigmented renal epithelioid AML specimens. Clinical presentations, histopathological features, immunohistochemical profiles, and molecular findings were analyzed. Both specimens exhibited melanin pigmentation, and 1 tumor demonstrated unique molecular alterations, including and mutations. This study underscores the importance of meticulous histopathological evaluation and molecular profiling in diagnosing and managing this extremely rare variant of epithelioid AML.
MeSH Terms
Humans; Angiomyolipoma; Kidney Neoplasms; Female; Biomarkers, Tumor; Middle Aged; Male; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Protein p53; Kidney; Diagnosis, Differential; Melanins; Nephrectomy; Retrospective Studies; Mutation