Dermal Metastasis From Head and Neck Squamous Cell Carcinoma: Systematic Review and Pooled Analysis.
TL;DR
The role of NK cells in AML immune surveillance, mechanisms by which their function becomes impaired in the disease, and the current therapeutic approaches harnessing NK cells in AML management are outlined.
OpenAlex 토픽 ·
Cancer Diagnosis and Treatment
Nonmelanoma Skin Cancer Studies
Head and Neck Cancer Studies
The role of NK cells in AML immune surveillance, mechanisms by which their function becomes impaired in the disease, and the current therapeutic approaches harnessing NK cells in AML management are ou
- p-value p = 0.036
- 95% CI 0.32-0.96
- HR 0.55
- 연구 설계 systematic review
APA
Luke Stanisce, Sabrina R Comess, et al. (2026). Dermal Metastasis From Head and Neck Squamous Cell Carcinoma: Systematic Review and Pooled Analysis.. The Laryngoscope, 136(5), 2001-2007. https://doi.org/10.1002/lary.70298
MLA
Luke Stanisce, et al.. "Dermal Metastasis From Head and Neck Squamous Cell Carcinoma: Systematic Review and Pooled Analysis.." The Laryngoscope, vol. 136, no. 5, 2026, pp. 2001-2007.
PMID
41328027
Abstract
[OBJECTIVE] Dermal metastasis from head and neck squamous cell carcinoma (HNSCC) is a rare and poorly understood manifestation of advanced disease, historically linked to poor prognosis. This systematic review aims to better characterize the clinical associations, treatment paradigms, and survival outcomes associated with this entity.
[DATA SOURCES] PubMed, Embase, and Scopus databases were systematically searched through May 1, 2025.
[REVIEW METHODS] The protocol was registered on PROSPERO, and the systematic review was reported in accordance with PRISMA guidelines. Patient-level data on demographics, disease characteristics, treatments, and survival outcomes were extracted from cases, and pooled analyses were conducted using logistic regression, Kaplan-Meier survival estimates, and Cox proportional hazards regression.
[RESULTS] Seventy-eight studies comprising 279 cases were included. Most patients were male (83%). The majority had advanced-stage primary disease (87%) originating in the oral cavity (42%), larynx (21%), and oropharynx (18%). Dermal metastases most often affected the neck (57%) or trunk (23%). Median survival following diagnosis was 3.5 months. The receipt of treatment was independently associated with a 45% lower hazard of death compared with no treatment (HR: 0.55; 95% CI: 0.32-0.96; p = 0.036), although no individual modality conferred a significant survival advantage. Primary tumor characteristics, anatomical location of dermal lesions, and the presence of locoregional or distant metastatic disease were not predictive of survival.
[CONCLUSIONS] Dermal metastasis from HNSCC signifies aggressive disease with limited survival. These findings underscore the importance of individualized patient counseling and the need for further research into effective therapeutic strategies.
[DATA SOURCES] PubMed, Embase, and Scopus databases were systematically searched through May 1, 2025.
[REVIEW METHODS] The protocol was registered on PROSPERO, and the systematic review was reported in accordance with PRISMA guidelines. Patient-level data on demographics, disease characteristics, treatments, and survival outcomes were extracted from cases, and pooled analyses were conducted using logistic regression, Kaplan-Meier survival estimates, and Cox proportional hazards regression.
[RESULTS] Seventy-eight studies comprising 279 cases were included. Most patients were male (83%). The majority had advanced-stage primary disease (87%) originating in the oral cavity (42%), larynx (21%), and oropharynx (18%). Dermal metastases most often affected the neck (57%) or trunk (23%). Median survival following diagnosis was 3.5 months. The receipt of treatment was independently associated with a 45% lower hazard of death compared with no treatment (HR: 0.55; 95% CI: 0.32-0.96; p = 0.036), although no individual modality conferred a significant survival advantage. Primary tumor characteristics, anatomical location of dermal lesions, and the presence of locoregional or distant metastatic disease were not predictive of survival.
[CONCLUSIONS] Dermal metastasis from HNSCC signifies aggressive disease with limited survival. These findings underscore the importance of individualized patient counseling and the need for further research into effective therapeutic strategies.
MeSH Terms
Humans; Skin Neoplasms; Squamous Cell Carcinoma of Head and Neck; Head and Neck Neoplasms; Male; Prognosis; Female