Optimizing Natural Killer Cellular Therapy in Acute Myeloid Leukemia.
2/5 보강
TL;DR
A case report of IRMT initially diagnosed as rhabdomyosarcoma based on a core needle biopsy specimen, which was overdiagnosed, is presented and the clinicopathological features of this tumor are reviewed, aiming to enhance understanding of this type of tumor.
OpenAlex 토픽 ·
Immune Cell Function and Interaction
CAR-T cell therapy research
Acute Myeloid Leukemia Research
A case report of IRMT initially diagnosed as rhabdomyosarcoma based on a core needle biopsy specimen, which was overdiagnosed, is presented and the clinicopathological features of this tumor are revie
APA
Binsah George, Manu Pandey, et al. (2026). Optimizing Natural Killer Cellular Therapy in Acute Myeloid Leukemia.. American journal of clinical oncology, 49(5), 247-256. https://doi.org/10.1097/COC.0000000000001262
MLA
Binsah George, et al.. "Optimizing Natural Killer Cellular Therapy in Acute Myeloid Leukemia.." American journal of clinical oncology, vol. 49, no. 5, 2026, pp. 247-256.
PMID
41332227 ↗
Abstract 한글 요약
Acute myeloid leukemia (AML) continues to pose a major hurdle in hematologic oncology, driven by its genetic complexity and tendency to resist standard therapies. Even with progress in treatment-such as high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT)-outcomes remain unsatisfactory for many patients. In recent years, immunotherapy has emerged as an appealing strategy to improve survival by strengthening the body's own anti-leukemia defenses. Natural killer (NK) cells, a critical component of innate immunity, have shown strong potential for directly eliminating AML cells without prior antigen exposure. This review outlines the role of NK cells in AML immune surveillance, mechanisms by which their function becomes impaired in the disease, and the current therapeutic approaches harnessing NK cells in AML management. We also discuss key obstacles and opportunities, including strategies to boost NK cell activity, counter immune escape, and improve treatment durability. Continued investigation is essential to refine NK cell-based therapies and bring patient-tailored immunotherapeutic options into broader clinical use.
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