The role of lactic acid metabolism in anti-tumor immunity.
TL;DR
The authors suggest a similar evaluation in other European countries noting that beyond infrastructure and technology, personnel training and improved communication skills are essential for optimizing biomarker testing and personalized treatment approaches.
OpenAlex 토픽 ·
Cancer, Hypoxia, and Metabolism
Ferroptosis and cancer prognosis
Immune cells in cancer
The authors suggest a similar evaluation in other European countries noting that beyond infrastructure and technology, personnel training and improved communication skills are essential for optimizing
APA
Zhenhao Wang, Du Hanlin, et al. (2026). The role of lactic acid metabolism in anti-tumor immunity.. Critical reviews in oncology/hematology, 221, 105183. https://doi.org/10.1016/j.critrevonc.2026.105183
MLA
Zhenhao Wang, et al.. "The role of lactic acid metabolism in anti-tumor immunity.." Critical reviews in oncology/hematology, vol. 221, 2026, pp. 105183.
PMID
41655750
Abstract
Recent studies have highlighted the pivotal role of lactate metabolism in key oncological processes, such as tumor proliferation, resistance and immune evasion. The discovery of histone lactylation pathways has further underscored the essential link between cellular energy metabolism and epigenetics, offering new insights into cancer biology. This review provides a systematic overview of lactate-immune crosstalk within the tumor microenvironment (TME), discusses the clinical relevance of lactate metabolism and lactylation biomarkers, and highlights emerging therapeutic strategies that target lactate-related pathways. By elucidating the lactate-regulated networks in cancer progression, this review offers insights into the underlying molecular mechanisms and potential pathways for the development of targeted therapies.
MeSH Terms
Humans; Neoplasms; Tumor Microenvironment; Lactic Acid; Energy Metabolism; Animals
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