Polycystic ovarian syndrome - Exploring the therapeutic and biomedical insights into the role of silver nanoparticles.
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TL;DR
An uncommon overview of the mechanism of action and safety of AgNPs that are biosynthesized to treat the PCOS condition is provided, which includes evidence from insulin, inflammation, oxidative processes, neuroendocrine factors and cystogenic pathways to combine and provide an overview.
OpenAlex 토픽 ·
Ovarian function and disorders
Reproductive System and Pregnancy
Reproductive Biology and Fertility
An uncommon overview of the mechanism of action and safety of AgNPs that are biosynthesized to treat the PCOS condition is provided, which includes evidence from insulin, inflammation, oxidative proce
APA
Dhanyaa Muthukumaran, Anitha, et al. (2026). Polycystic ovarian syndrome - Exploring the therapeutic and biomedical insights into the role of silver nanoparticles.. The Journal of steroid biochemistry and molecular biology, 259, 106968. https://doi.org/10.1016/j.jsbmb.2026.106968
MLA
Dhanyaa Muthukumaran, et al.. "Polycystic ovarian syndrome - Exploring the therapeutic and biomedical insights into the role of silver nanoparticles.." The Journal of steroid biochemistry and molecular biology, vol. 259, 2026, pp. 106968.
PMID
41707839 ↗
Abstract 한글 요약
A prevalent endocrinopathy affecting reproductive-age women is polycystic ovarian syndrome (PCOS), which affects around 5-20 % of these individuals. PCOS is closely linked to the following causes: immunological, endocrine, and reactive oxygen species (ROS). Plant extracts are used in the synthesis of silver nanoparticles (AgNPs), which are employed for PCOS treatment. Ag NPs can regulate the hormonal imbalance, reducing pro-inflammatory cytokines and ovarian cysts in PCOS. Conventional medicines, such as metformin, clomiphene citrate, letrozole, flutamide, and rosiglitazone, can regulate menstrual irregularities, improve ovulation, reduce insulin resistance, and decrease androgen levels, but may also cause various side effects. As a result, AgNPs are more effective at optimized doses in the short term used in the treatment of PCOS. The present article provides an uncommon overview of the mechanism of action and safety of AgNPs that are biosynthesized to treat the PCOS condition. The review includes evidence from insulin, inflammation, oxidative processes, neuroendocrine factors and cystogenic pathways to combine and provide an overview. The review also discusses how to approach toxicity, especially dose-dependent, and the reproductive safety of AgNPs and their translational limitations to define the boundaries of AgNPs in the treatment of PCOS.
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