The Clinical Relevance of Lymph Node Ratio for Post-Mastectomy Radiotherapy in Triple-Negative Breast Cancer: A Real-World Analysis With Propensity Score Matching Using SEER Database.
2/5 보강
PICO 자동 추출 (휴리스틱, conf 2/4)
유사 논문P · Population 대상 환자/모집단
추출되지 않음
I · Intervention 중재 / 시술
mastectomy
C · Comparison 대조 / 비교
추출되지 않음
O · Outcome 결과 / 결론
[CONCLUSION] PMRT substantially improves the survival outcomes for individuals who fall into the intermediate to high-risk groups as determined by LNR, an essential prognostic factor. This helps in developing personalized PMRT treatment strategies for TNBC patients, thereby enabling precision medicine approaches.
OpenAlex 토픽 ·
Breast Cancer Treatment Studies
Breast Implant and Reconstruction
Lymphatic System and Diseases
[BACKGROUND] To define the role of post-mastectomy radiotherapy (PMRT) in triple-negative breast cancer (TNBC), employing lymph node ratio (LNR, ratio of positive over excised lymph nodes) to offer pe
- p-value p = 0.021
- p-value p = 0.003
- HR 0.898
APA
Weihong Zheng, J Sun, et al. (2026). The Clinical Relevance of Lymph Node Ratio for Post-Mastectomy Radiotherapy in Triple-Negative Breast Cancer: A Real-World Analysis With Propensity Score Matching Using SEER Database.. Cancer medicine, 15(5), e71882. https://doi.org/10.1002/cam4.71882
MLA
Weihong Zheng, et al.. "The Clinical Relevance of Lymph Node Ratio for Post-Mastectomy Radiotherapy in Triple-Negative Breast Cancer: A Real-World Analysis With Propensity Score Matching Using SEER Database.." Cancer medicine, vol. 15, no. 5, 2026, pp. e71882.
PMID
42043849 ↗
Abstract 한글 요약
[BACKGROUND] To define the role of post-mastectomy radiotherapy (PMRT) in triple-negative breast cancer (TNBC), employing lymph node ratio (LNR, ratio of positive over excised lymph nodes) to offer personalized treatment strategies for this aggressively behaving cancer type.
[METHODS] The study included a total of 6474 women diagnosed with T1-4 N1-3 M0 TNBC from 2010 to 2017 using the SEER database, all of whom underwent mastectomy. Breast cancer-specific survival (BCSS) was defined as the time from diagnosis until death attributable to the breast cancer. Overall survival (OS) was defined as the time from diagnosis until death from any cause. A 1:1 propensity score matching (PSM) method was utilized to balance the baseline characteristics between the PMRT and non-PMRT groups. Kaplan-Meier analysis, together with the log-rank test, was applied to estimate survival outcomes.
[RESULTS] After PSM, the PMRT group displayed better OS (HR = 0.898, 95% CI = 0.819-0.984, p = 0.021). Subgroup analyses indicated that PMRT improved BCSS outcomes in the high-LNR group (HR = 0.762, 95% CI = 0.636-0.913; p = 0.003) rather than low- (HR = 1.125, 95% CI = 0.938-1.348; p = 0.203) or intermediate-LNR groups (HR = 0.925, 95% CI = 0.778-1.099; p = 0.374). Compared with the non-PMRT group, patients receiving PMRT had better OS in the intermediate-LNR (HR = 0.834, 95% CI = 0.715-0.972, p = 0.021) and high-LNR groups (HR = 0.757, 95% CI = 0.643-0.893, p = 0.001), whereas the difference was not significant in the low-LNR group (HR = 1.044, 95% CI = 0.889-1.226, p = 0.599).
[CONCLUSION] PMRT substantially improves the survival outcomes for individuals who fall into the intermediate to high-risk groups as determined by LNR, an essential prognostic factor. This helps in developing personalized PMRT treatment strategies for TNBC patients, thereby enabling precision medicine approaches.
[METHODS] The study included a total of 6474 women diagnosed with T1-4 N1-3 M0 TNBC from 2010 to 2017 using the SEER database, all of whom underwent mastectomy. Breast cancer-specific survival (BCSS) was defined as the time from diagnosis until death attributable to the breast cancer. Overall survival (OS) was defined as the time from diagnosis until death from any cause. A 1:1 propensity score matching (PSM) method was utilized to balance the baseline characteristics between the PMRT and non-PMRT groups. Kaplan-Meier analysis, together with the log-rank test, was applied to estimate survival outcomes.
[RESULTS] After PSM, the PMRT group displayed better OS (HR = 0.898, 95% CI = 0.819-0.984, p = 0.021). Subgroup analyses indicated that PMRT improved BCSS outcomes in the high-LNR group (HR = 0.762, 95% CI = 0.636-0.913; p = 0.003) rather than low- (HR = 1.125, 95% CI = 0.938-1.348; p = 0.203) or intermediate-LNR groups (HR = 0.925, 95% CI = 0.778-1.099; p = 0.374). Compared with the non-PMRT group, patients receiving PMRT had better OS in the intermediate-LNR (HR = 0.834, 95% CI = 0.715-0.972, p = 0.021) and high-LNR groups (HR = 0.757, 95% CI = 0.643-0.893, p = 0.001), whereas the difference was not significant in the low-LNR group (HR = 1.044, 95% CI = 0.889-1.226, p = 0.599).
[CONCLUSION] PMRT substantially improves the survival outcomes for individuals who fall into the intermediate to high-risk groups as determined by LNR, an essential prognostic factor. This helps in developing personalized PMRT treatment strategies for TNBC patients, thereby enabling precision medicine approaches.
🏷️ 키워드 / MeSH 📖 같은 키워드 OA만
- Humans
- Triple Negative Breast Neoplasms
- Female
- SEER Program
- Mastectomy
- Propensity Score
- Middle Aged
- Aged
- Lymph Node Ratio
- Adult
- Radiotherapy
- Adjuvant
- Lymph Nodes
- Kaplan-Meier Estimate
- Lymphatic Metastasis
- Retrospective Studies
- Clinical Relevance
- SEER database
- lymph node ratio
- post‐mastectomy radiotherapy
- survival analysis
- triple‐negative breast cancer
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