Selective tumor accumulation as a route to precision medicine for platinum anticancer drugs.
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TL;DR
The work showing that glycosaminoglycans (GAGs) are mediators of platinum complex cellular accumulation is summarized, adding to the understanding of the tumor uptake of platinum anticancer drugs and suggesting avenues toward precision medicine for platinums based on patient stratification.
OpenAlex 토픽 ·
Proteoglycans and glycosaminoglycans research
Angiogenesis and VEGF in Cancer
Nanoparticle-Based Drug Delivery
The work showing that glycosaminoglycans (GAGs) are mediators of platinum complex cellular accumulation is summarized, adding to the understanding of the tumor uptake of platinum anticancer drugs and
APA
Erica J. Peterson, Nicholas P. Farrell (2026). Selective tumor accumulation as a route to precision medicine for platinum anticancer drugs.. Journal of inorganic biochemistry, 279, 113267. https://doi.org/10.1016/j.jinorgbio.2026.113267
MLA
Erica J. Peterson, et al.. "Selective tumor accumulation as a route to precision medicine for platinum anticancer drugs.." Journal of inorganic biochemistry, vol. 279, 2026, pp. 113267.
PMID
41759461 ↗
Abstract 한글 요약
This brief review summarizes our work showing that glycosaminoglycans (GAGs) are mediators of platinum complex cellular accumulation. Especially, there is an inverse relationship whereby charged polynuclear platinum complexes exemplified by BBR3464 and BBR3571 show enhanced tumor accumulation and antitumor efficacy in presence of a high level of GAGs whereas the inverse relationship occurs for the neutral mononuclear carboplatin. These results add to our understanding of the tumor uptake of platinum anticancer drugs and suggest avenues toward precision medicine for platinums based on patient stratification.
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